EBV-specific cytotoxic T lymphocytes protect against human EBV-associated lymphoma in scid mice

被引：22

作者：

Buchsbaum, RJ

Fabry, JA

Lieberman, J

机构：

[1] TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED,DIV HEMATOL ONCOL,BOSTON,MA 02111

[2] HARVARD UNIV,SCH MED,CTR BLOOD RES,BOSTON,MA 02115

来源：

IMMUNOLOGY LETTERS | 1996年 / 52卷 / 2-3期

关键词：

Epstein-Barr virus (EBV); cytotoxic T lymphocyte (CTL); lymphoma; scid mice;

D O I：

10.1016/0165-2478(96)02602-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Scid mice develop human EBV-positive B cell tumors after injection with EBV-transformed human B cells or peripheral blood lymphocytes from EBV-seropositive donors. Injection of cytotoxic T cell (CTL) lines, selectively expanded in vitro to recognize autologous EBV-transformed B cells, protected mice against developing human lymphoproliferative disease. CTL protection required a single dose of polyethylene-glycol-conjugated IL2. Mice were not protected by CTL that did not specifically recognize EBV-transformed B cells or by mitogen-activated lymphocytes.

引用

页码：145 / 152

页数：8

共 50 条

[21] Towards Gene Therapy for EBV-Associated Post-Transplant Lymphoproliferative Disease: Genetically Modified EBV-Specific Cytotoxic T Lymphocytes Induce Regression of Autologous EBV-Induced Lymphoproliferation Despite Immunosuppression
Ricciardelli, Ida
Blundell, Mike
Brewin, Jennifer
Amrolia, Persis J.
Pule, Martin
MOLECULAR THERAPY, 2014, 22 : S62 - S63
[22] Cell therapy with EBV-specific cytotoxic T-lymphocytes for patients with nasopharingeal carcinoma
Comoli, P.
Secondino, S.
Licitra, L. F.
Schiavo, R.
Schiavetto, I.
Gurrado, A.
Locati, L.
Pedrazzoli, P.
Locatelli, F.
Siena, S.
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)
[23] Treatment of EBV plus nasopharyngeal carcinoma with banked EBV-specific cytotoxic T cells
Prockop, Susan
Doubrovina, Ekatarina
Baxi, Shrujal S.
Escobedo, Virginia
Suser, Stephanie
Szenes, Victoria
Pfister, David G.
O'Reilly, Richard J.
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
[24] T cell therapy with EBV-specific cytotoxic T-lymphocytes for patients with nasopharyngeal carcinoma
Pedrazzoli, P.
Comoli, P.
Secondino, S.
Gurrado, A.
Pagani, A.
Zecca, M.
ANNALS OF ONCOLOGY, 2018, 29 : 11 - 11
[25] Resolution of EBV+ CNS lymphoma with appearance of CSF EBV-specific T cells
de Beukelaar, JW
van Arkel, C
van den Bent, MJ
Van't Veer, MB
van Doornum, GJ
Cornelissen, JJ
Smitt, PAS
Gratama, JW
ANNALS OF NEUROLOGY, 2005, 58 (05) : 788 - 792
[26] EBV-specific cytotoxic T-lymphocytes derived from umbilical cord blood and from EBV seronegative donors.
Lucas, KG
Pollok, K
Emanuel, DE
EXPERIMENTAL HEMATOLOGY, 1996, 24 (09) : 27 - 27
[27] EFFECT OF INHALED CORTICOSTEROIDS ON EBV-SPECIFIC CYTOTOXIC T-CELLS AND EBV OROPHARYNGEAL EXCRETION
ABO, W
IMAI, S
SUGIURA, M
TERAI, N
OSATO, T
SHIMANO, Y
CHIBA, S
LANCET, 1992, 340 (8819): : 606 - 606
[28] Rapid Generation of EBV-Specific Cytotoxic T Lymphocytes Resistant to Calcineurin Inhibitors for Adoptive Immunotherapy
Ricciardelli, I.
Brewin, J.
Lugthart, G.
Albon, S. J.
Pule, M.
Amrolia, P. J.
AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 (12) : 3244 - 3252
[29] Cell therapy with autologous EBV-specific cytotoxic T-lymphocytes for patients with nasopharyngeal carcinoma
Comoli, P.
Pedrazzoli, P.
Licitra, L.
Secondino, S.
Gurrado, A.
Schiavo, R.
Basso, S.
Schiavetto, I.
Caruana, I.
Maccario, R.
Locatelli, F.
Siena, S.
BONE MARROW TRANSPLANTATION, 2010, 45 : S30 - S31
[30] GENERATION OF EBV-SPECIFIC AND EBV-SPECIFIC, TCR-REPROGRAMMED HUMAN CD8+CYTOTOXIC T LYMPHOCYTES WITH STEM CELL MEMORY AND CENTRAL MEMORY PROPERTIES BY MODULATING GLYCOLYTIC T CELL METABOLISM
Weber, I.
Khan, S.
Theobald, M.
Hartwig, U. F.
HAEMATOLOGICA, 2015, 100 : 171 - 171

← 1 2 3 4 5 →