EBV-specific cytotoxic T lymphocytes protect against human EBV-associated lymphoma in scid mice

被引：22
|
作者：
Buchsbaum, RJ
Fabry, JA
Lieberman, J
机构：
[1] TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED,DIV HEMATOL ONCOL,BOSTON,MA 02111
[2] HARVARD UNIV,SCH MED,CTR BLOOD RES,BOSTON,MA 02115
来源：
IMMUNOLOGY LETTERS | 1996年 / 52卷 / 2-3期
关键词：
Epstein-Barr virus (EBV); cytotoxic T lymphocyte (CTL); lymphoma; scid mice;
D O I：
10.1016/0165-2478(96)02602-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Scid mice develop human EBV-positive B cell tumors after injection with EBV-transformed human B cells or peripheral blood lymphocytes from EBV-seropositive donors. Injection of cytotoxic T cell (CTL) lines, selectively expanded in vitro to recognize autologous EBV-transformed B cells, protected mice against developing human lymphoproliferative disease. CTL protection required a single dose of polyethylene-glycol-conjugated IL2. Mice were not protected by CTL that did not specifically recognize EBV-transformed B cells or by mitogen-activated lymphocytes.
引用
收藏
页码：145 / 152
页数：8
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