Adalimumab in Elderly Patients with Non-Infectious Uveitis. Safety and Efficacy

被引：8

作者：

Moll-Udina, Aina ^{[1
]}

Miguel Escuder, Lucia ^{[1
]}

Hernanz, Ines ^{[1
]}

Llorenc, Victor ^{[1
]}

Fonollosa, Alex ^{[2
]}

Cordero Coma, Miguel ^{[3
]}

Sainz de la Maza, Maite ^{[1
]}

Espinosa, Gerard ^{[4
]}

Gonzalez Guijarro, J. Jacobo ^{[5
]}

Lopez Lopez, Fernando ^{[6
]}

Alba-Linero, Carmen ^{[7
]}

Hernandez, Marisa ^{[8
]}

Martinez Costa, Lucia ^{[9
]}

Celdran Vivancos, Diego ^{[5
]}

Giralt, Lena ^{[2
]}

Artaraz, Joseba ^{[2
]}

Soler Bartrina, Pablo ^{[10
]}

Jodar Marquez, Margarita ^{[7
]}

Garcia de Vicuna, Rosario ^{[11
]}

Esquinas, Cristina ^{[12
]}

Adan, Alfredo ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin, Ophthalmol Clin Inst, Dept Ophthalmol, Barcelona, Spain

[2] Univ Basque Country, Cruces Hosp, BioCruces Hlth Res Inst, Dept Ophthalmol, Leioa, Spain

[3] Univ Leon, Univ Hosp Leon, Dept Ophthalmol, IBIOMED, Leon, Spain

[4] Univ Barcelona, Hosp Clin, Dept Autoimmune Dis, Barcelona, Spain

[5] Univ Hosp La Princesa, Dept Ophthalmol, Madrid, Spain

[6] Santiago Hosp, Dept Ophthalmol, Santiago De Compostela, Spain

[7] Univ Malaga, Reg Univ Hosp Malaga, Dept Ophthalmol, Malaga, Spain

[8] Gen Hosp Valencia, Dept Ophthalmol, Valencia, Spain

[9] Univ Dr Peset Hosp, Dept Ophthalmol, Valencia, Spain

[10] Bierzo Hosp, Dept Ophthalmol, Leon, Spain

[11] Univ Hosp La Princesa, Dept Rheumatol, Madrid, Spain

[12] Autonomous Univ Barcelona, Vall Hebron Res Inst, Barcelona, Spain

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2021年 / 29卷 / 7-8期

关键词：

Uveitis; uveitic macular edema; adalimumab; elderly; adverse events; efficacy; safety; ANTITUMOR NECROSIS FACTOR; FACTOR-ALPHA THERAPIES; ANTI-TNF THERAPY; RHEUMATOID-ARTHRITIS; BIOLOGIC AGENTS; STANDARDIZATION; IMMUNOGENICITY; METHOTREXATE; EPIDEMIOLOGY; MANAGEMENT;

D O I：

10.1080/09273948.2020.1769139

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose To assess the efficacy and safety of adalimumab in elderly patients with noninfectious uveitis (NIU). Methods An observational, retrospective, multicenter study was done. Changes in best-corrected visual acuity (BCVA), inflammatory activity parameters, central retinal thickness (CRT), and the occurrence of adverse events (AE) developed during follow-up were recorded. Results A total of 82 eyes from 41 patients 60 years of age and older with noninfectious uveitis treated with adalimumab were included. A significant improvement in BCVA (71.5 to 75.4 letters,p= .001) and in CRT (311.1 mu m to 265 mu m,p= .001) was observed. Moreover, a significant decrease from baseline in the rate of patients with anterior chamber cell (ACC) >0+ (34.6% to 5.7%,p= <0.001) or vitreous haze>0+ (21.3% to 4.3%,p= .002) was determined. AEs were observed in 11 patients (26.8%). Conclusion Adalimumab can be safe and efficacious for the treatment of NIU in patients 60 years of age and older.

引用

页码：1591 / 1598

页数：8

共 50 条

[31] Adalimumab for the Treatment of Non-Infectious Uveitis: A Real Life Experience
Raad, Fatima
Luque, Paula
Ledo, Sofia Garcia
Lozano, Alicia Alda
Llorens, Victor
Espejo, Antonio
Heras, Henar
Santana, Lucia
Trapiella, Luis
Fanlo, Patricia
Adan, Alfredo
Espinosa, Gerard
Navarrete, Nuria
[J]. OCULAR IMMUNOLOGY AND INFLAMMATION, 2024,
[32] Adalimumab for the treatment of refractory active and inactive non-infectious uveitis
Lee, Jonathan T. L.
Yates, William B.
Rogers, Sophie
Wakefield, Denis
McCluskey, Peter
Lim, Lyndell L.
[J]. BRITISH JOURNAL OF OPHTHALMOLOGY, 2018, 102 (12) : 1672 - 1678
[33] The Efficacy of Adalimumab in Children with Chronic Non-infectious Posterior Uveitis and Panuveitis: A Retrospective Cohort Study
Tao, Tianyu
Yang, Shizhao
He, Daquan
Peng, Xuening
Wang, Zhenyu
Jiang, Qi
Wang, Tianfu
Su, Wenru
[J]. OPHTHALMOLOGY AND THERAPY, 2024, 13 (05) : 1239 - 1253
[34] The Efficacy of Adalimumab in Children with Chronic Non-infectious Posterior Uveitis and Panuveitis: A Retrospective Cohort Study
Tianyu Tao
Shizhao Yang
Daquan He
Xuening Peng
Zhenyu Wang
Qi Jiang
Tianfu Wang
Wenru Su
[J]. Ophthalmology and Therapy, 2024, 13 : 1239 - 1253
[35] Efficacy and safety of the optimisation of biological therapy in non-infectious uveitis: Systematic review
Salido Olivares, Marina
Loza Santamaria, Estibaliz
[J]. SEMINARS IN ARTHRITIS AND RHEUMATISM, 2022, 52
[36] Efficacy and Safety of Adalimumab in Pediatric Non-infectious Non-anterior Uveitis: Real-life Experience From the International AIDA Network Uveitis Registry
Antonio Vitale
Francesca Della Casa
Silvana Guerriero
Gaafar Ragab
Angela Mauro
Valeria Caggiano
Marco Cattalini
Emanuela Del Giudice
Rossella Favale
Carla Gaggiano
Irene Bellicini
Maria Pia Paroli
Mohamed Tharwat Hegazy
Jurgen Sota
Abdurrahman Tufan
Alberto Balistreri
Ibrahim Almaghlouth
Francesco La Torre
Ewa Więsik-Szewczyk
Maria Tarsia
Andrea Hinojosa-Azaola
Eduardo Martín-Nares
Bruno Frediani
Gian Marco Tosi
Alex Fonollosa
José Hernández-Rodríguez
Rana Hussein Amin
Giuseppe Lopalco
Donato Rigante
Luca Cantarini
Claudia Fabiani
[J]. Ophthalmology and Therapy, 2023, 12 : 1957 - 1971
[37] EFFICACY AND SAFETY OF THE OPTIMISATION OF BIOLOGICAL THERAPY IN NON-INFECTIOUS UVEITIS: SYSTEMATIC REVIEW
Olivares, M. Salido
Loza, E.
[J]. ANNALS OF THE RHEUMATIC DISEASES, 2022, 81 : 1743 - 1743
[38] Efficacy and Safety of Adalimumab in Pediatric Non-infectious Non-anterior Uveitis: Real-life Experience From the International AIDA Network Uveitis Registry
Vitale, Antonio
Della Casa, Francesca
Guerriero, Silvana
Ragab, Gaafar
Mauro, Angela
Caggiano, Valeria
Cattalini, Marco
Del Giudice, Emanuela
Favale, Rossella
Gaggiano, Carla
Bellicini, Irene
Paroli, Maria Pia
Hegazy, Mohamed Tharwat
Sota, Jurgen
Tufan, Abdurrahman
Balistreri, Alberto
Almaghlouth, Ibrahim
La Torre, Francesco
Wiesik-Szewczyk, Ewa
Tarsia, Maria
Hinojosa-Azaola, Andrea
Martin-Nares, Eduardo
Frediani, Bruno
Tosi, Gian Marco
Fonollosa, Alex
Hernandez-Rodriguez, Jose
Amin, Rana Hussein
Lopalco, Giuseppe
Rigante, Donato
Cantarini, Luca
Fabiani, Claudia
[J]. OPHTHALMOLOGY AND THERAPY, 2023, 12 (04) : 1957 - 1971
[39] Effect of Adalimumab on Peripheral Blood Mononuclear Cells in Non-Infectious Uveitis
Walscheid, Karoline
Weinhage, Toni
Foell, Dirk
Heinz, Carsten
Kasper, Maren
Heiligenhaus, Arnd
[J]. OCULAR IMMUNOLOGY AND INFLAMMATION, 2019, 27 (02) : 330 - 337
[40] Real-World outcomes of adalimumab in adults with non-infectious uveitis
Leal, Ines
Wong, Shiao Wei
Giuffre, Chiara
Patil, Ajay
Sousa, David Cordeiro
Barbosa-Breda, Joao
Chhabra, Ramandeep
Jones, Nicholas P.
Steeples, Laura R.
[J]. ACTA OPHTHALMOLOGICA, 2022, 100 (07) : E1496 - E1502

← 1 2 3 4 5 →