Adalimumab in Elderly Patients with Non-Infectious Uveitis. Safety and Efficacy

被引：8

作者：

Moll-Udina, Aina ^{[1
]}

Miguel Escuder, Lucia ^{[1
]}

Hernanz, Ines ^{[1
]}

Llorenc, Victor ^{[1
]}

Fonollosa, Alex ^{[2
]}

Cordero Coma, Miguel ^{[3
]}

Sainz de la Maza, Maite ^{[1
]}

Espinosa, Gerard ^{[4
]}

Gonzalez Guijarro, J. Jacobo ^{[5
]}

Lopez Lopez, Fernando ^{[6
]}

Alba-Linero, Carmen ^{[7
]}

Hernandez, Marisa ^{[8
]}

Martinez Costa, Lucia ^{[9
]}

Celdran Vivancos, Diego ^{[5
]}

Giralt, Lena ^{[2
]}

Artaraz, Joseba ^{[2
]}

Soler Bartrina, Pablo ^{[10
]}

Jodar Marquez, Margarita ^{[7
]}

Garcia de Vicuna, Rosario ^{[11
]}

Esquinas, Cristina ^{[12
]}

Adan, Alfredo ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin, Ophthalmol Clin Inst, Dept Ophthalmol, Barcelona, Spain

[2] Univ Basque Country, Cruces Hosp, BioCruces Hlth Res Inst, Dept Ophthalmol, Leioa, Spain

[3] Univ Leon, Univ Hosp Leon, Dept Ophthalmol, IBIOMED, Leon, Spain

[4] Univ Barcelona, Hosp Clin, Dept Autoimmune Dis, Barcelona, Spain

[5] Univ Hosp La Princesa, Dept Ophthalmol, Madrid, Spain

[6] Santiago Hosp, Dept Ophthalmol, Santiago De Compostela, Spain

[7] Univ Malaga, Reg Univ Hosp Malaga, Dept Ophthalmol, Malaga, Spain

[8] Gen Hosp Valencia, Dept Ophthalmol, Valencia, Spain

[9] Univ Dr Peset Hosp, Dept Ophthalmol, Valencia, Spain

[10] Bierzo Hosp, Dept Ophthalmol, Leon, Spain

[11] Univ Hosp La Princesa, Dept Rheumatol, Madrid, Spain

[12] Autonomous Univ Barcelona, Vall Hebron Res Inst, Barcelona, Spain

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2021年 / 29卷 / 7-8期

关键词：

Uveitis; uveitic macular edema; adalimumab; elderly; adverse events; efficacy; safety; ANTITUMOR NECROSIS FACTOR; FACTOR-ALPHA THERAPIES; ANTI-TNF THERAPY; RHEUMATOID-ARTHRITIS; BIOLOGIC AGENTS; STANDARDIZATION; IMMUNOGENICITY; METHOTREXATE; EPIDEMIOLOGY; MANAGEMENT;

D O I：

10.1080/09273948.2020.1769139

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose To assess the efficacy and safety of adalimumab in elderly patients with noninfectious uveitis (NIU). Methods An observational, retrospective, multicenter study was done. Changes in best-corrected visual acuity (BCVA), inflammatory activity parameters, central retinal thickness (CRT), and the occurrence of adverse events (AE) developed during follow-up were recorded. Results A total of 82 eyes from 41 patients 60 years of age and older with noninfectious uveitis treated with adalimumab were included. A significant improvement in BCVA (71.5 to 75.4 letters,p= .001) and in CRT (311.1 mu m to 265 mu m,p= .001) was observed. Moreover, a significant decrease from baseline in the rate of patients with anterior chamber cell (ACC) >0+ (34.6% to 5.7%,p= <0.001) or vitreous haze>0+ (21.3% to 4.3%,p= .002) was determined. AEs were observed in 11 patients (26.8%). Conclusion Adalimumab can be safe and efficacious for the treatment of NIU in patients 60 years of age and older.

引用

页码：1591 / 1598

页数：8

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