Total synthesis of (±)-ganocins B and C

被引：13

作者：

Liu, Yao ^{[1
]}

Zhou, Chu-Jun ^{[1
]}

Li, Qingjiang ^{[1
,2
]}

Wang, Honggen ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[2] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 44期

基金：

中国国家自然科学基金;

关键词：

GOLD CATALYSIS; GANODERMA-LUCIDUM; POLYCYCLIC MEROTERPENOIDS; ANTIOXIDANT; POLYSACCHARIDES; ANTITUMOR; COCHLEAR; POTENT;

D O I：

10.1039/c6ob02049f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of structurally unique polycyclic phenolic meroterpenoids, ganocins B and C is reported. The synthesis features gold-catalyzed intramolecular cascade cyclization to construct the C/D ring bearing an angular methyl group, diastereo-selective Michael addition, and acid-mediated one-pot Robinson cyclization/deprotection/isomerization.

引用

页码：10362 / 10365

页数：4

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