6-Locus HLA allele and haplotype frequencies in a population of 1075 Russians from Karelia

被引：3

作者：

Hagenlocher, Yvonne ^{[1
]}

Willburger, Beatrix ^{[1
]}

Behrens, Geoffrey A. ^{[3
]}

Schmidt, Alexander H. ^{[1
,3
]}

Ioffe, Yuri ^{[2
]}

Sauter, Juergen ^{[1
]}

机构：

[1] DKMS German Bone Marrow Donor Ctr, Kressbach 1, D-72072 Tubingen, Germany

[2] Karelian Registry Unrelated Donors Hematopoiet St, Petrozavodsk, Russia

[3] DKMS Life Sci Lab, Dresden, Germany

来源：

HUMAN IMMUNOLOGY | 2019年 / 80卷 / 02期

关键词：

D O I：

10.1016/j.humimm.2018.10.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A total of 1075 Russians from the Russian part of Karelia were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 using next generation sequencing methods. The haplotypic and allelic profiles as well as Hardy-Weinberg proportions of this population sample were evaluated. As the most frequent 6-locus haplotype, A*03:01 g similar to B*07:02 g similar to C*07:02 g similar to DRB1*15:01 g similar to DQB1*06:02 g similar to DPB1*04:01 g was identified with an estimated frequency of 3.5%. No deviation from Hardy -Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Russia Karelia" and the identifier AFN3430.

引用

页码：95 / 96

页数：2

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