ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data

被引：117
|
作者：
Buck, MJ
Nobel, AB
Lieb, JD
机构：
[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Dept Stat, Chapel Hill, NC 27599 USA
来源：
GENOME BIOLOGY | 2005年 / 6卷 / 11期
关键词：
D O I：
10.1186/gb-2005-6-11-r97
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
ChIPOTle (Chromatin ImmunoPrecipitation On Tiled arrays) takes advantage of two unique properties of ChIP-chip data: the single-tailed nature of the data, caused by specific enrichment but not specific depletion of genomic fragments; and the predictable enrichment of DNA fragments adjacent to sites of direct protein-DNA interaction. Implemented as a Microsoft Excel macro written in Visual Basic, ChIPOTle uses a sliding window approach that yields improvements in the identification of bona fide sites of protein-DNA interaction.
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页数：8
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