Macrophages, Chronic Inflammation, and Insulin Resistance

被引：114

作者：

Li, He ^{[1
]}

Meng, Ya ^{[1
]}

He, Shuwang ^{[2
]}

Tan, Xiaochuan ^{[1
]}

Zhang, Yujia ^{[1
]}

Zhang, Xiuli ^{[1
]}

Wang, Lulu ^{[3
,4
]}

Zheng, Wensheng ^{[1
,4
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing City Key Lab Drug Delivery Technol & Nove, Beijing 100050, Peoples R China

[2] Shandong DYNE Marine Biopharmaceut Co Ltd, Rongcheng 264300, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China

[4] 1 Xian Nong Tan St, Beijing 100050, Peoples R China

来源：

CELLS | 2022年 / 11卷 / 19期

关键词：

obesity; macrophages; chronic inflammation; insulin resistance; molecular mechanism; TUMOR-NECROSIS-FACTOR; ALTERNATIVELY ACTIVATED MACROPHAGES; ADIPOSE-TISSUE INFLAMMATION; DIET-INDUCED OBESITY; N-TERMINAL KINASE; SKELETAL-MUSCLE INFLAMMATION; LOW-GRADE INFLAMMATION; TNF-ALPHA ANTIBODY; PPAR-GAMMA; IMMUNE CELLS;

D O I：

10.3390/cells11193001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The prevalence of obesity has reached alarming levels, which is considered a major risk factor for several metabolic diseases, including type 2 diabetes (T2D), non-alcoholic fatty liver, atherosclerosis, and ischemic cardiovascular disease. Obesity-induced chronic, low-grade inflammation may lead to insulin resistance, and it is well-recognized that macrophages play a major role in such inflammation. In the current review, the molecular mechanisms underlying macrophages, low-grade tissue inflammation, insulin resistance, and T2D are described. Also, the role of macrophages in obesity-induced insulin resistance is presented, and therapeutic drugs and recent advances targeting macrophages for the treatment of T2D are introduced.

引用

页数：24

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