P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) restrict the brain penetration of the Janus family of tyrosine kinase (JAK) inhibitor CYT387

被引:0
|
作者
Durmus, Selvi [1 ]
Xu, Ning [2 ]
Sparidans, Rolf W. [3 ]
Wagenaar, Els [1 ]
Beijnen, Jos H. [4 ]
Schinkel, Alfred H. [1 ]
机构
[1] Netherlands Canc Inst, Div Mol Oncol, Amsterdam, Netherlands
[2] China Japan Union Hosp, Changchun, Peoples R China
[3] Univ Utrecht, Fac Sci, Dept Pharmaceut Sci, Utrecht, Netherlands
[4] Slotervaart Hosp, Dept Pharm & Pharmacol, Amsterdam, Netherlands
来源
FASEB JOURNAL | 2013年 / 27卷
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
1103.1
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2)
    Kort, Anita
    Sparidans, Rolf W.
    Wagenaar, Els
    Beijnen, Jos H.
    Schinkel, Alfred H.
    PHARMACOLOGICAL RESEARCH, 2015, 102 : 200 - 207
  • [22] Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)
    Ieiri, Ichiro
    DRUG METABOLISM AND PHARMACOKINETICS, 2012, 27 (01) : 85 - 105
  • [23] Kinetic Analysis of the Cooperation of P-Glycoprotein (P-gp/Abcb1) and Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting the Brain and Testis Penetration of Erlotinib, Flavopiridol, and Mitoxantrone
    Kodaira, Hiroshi
    Kusuhara, Hiroyuki
    Ushiki, Junko
    Fuse, Eiichi
    Sugiyama, Yuichi
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 333 (03): : 788 - 796
  • [24] P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) limit brain accumulation of the FLT3 inhibitor quizartinib in mice
    Wang, Jing
    Gan, Changpei
    Retmana, Irene A.
    Sparidans, Rolf W.
    Li, Wenlong
    Lebre, Maria C.
    Beijnen, Jos H.
    Schinkel, Alfred H.
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 556 : 172 - 180
  • [25] Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration
    Tang, Seng Chuan
    Lagas, Jurjen S.
    Lankheet, Nienke A. G.
    Poller, Birk
    Hillebrand, Michel J.
    Rosing, Hilde
    Beijnen, Jos H.
    Schinkel, Alfred H.
    INTERNATIONAL JOURNAL OF CANCER, 2012, 130 (01) : 223 - 233
  • [26] Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Gene Dosage on Plasma Pharmacokinetics and Brain Accumulation of Dasatinib, Sorafenib, and Sunitinib
    Tang, Seng Chuan
    de Vries, Niels
    Sparidans, Rolf W.
    Wagenaar, Els
    Beijnen, Jos H.
    Schinkel, Alfred H.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2013, 346 (03): : 486 - 494
  • [27] Brain accumulation of osimertinib and its active metabolite AZ5104 is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein)
    van Hoppe, Stephanie
    Jamalpoor, Amer
    Rood, Johannes J. M.
    Wagenaar, Els
    Sparidans, Rolf W.
    Beijnen, Jos H.
    Schinkel, Alfred H.
    PHARMACOLOGICAL RESEARCH, 2019, 146
  • [28] Tivozanib reverses multidrug resistance mediated by ABCB1 (P-glycoprotein) and ABCG2 (BCRP)
    Yang, Danwen
    Kathawala, Rishil J.
    Chufan, Eduardo E.
    Patel, Atish
    Ambudkar, Suresh V.
    Chen, Zhe-Sheng
    Chen, Xiang
    FUTURE ONCOLOGY, 2014, 10 (11) : 1827 - 1841
  • [29] P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Localize in the Microvessels Forming the Blood-Tumor Barrier in Ependymomas
    Ginguene, Carole
    Champier, Jacques
    Maallem, Said
    Strazielle, Nathalie
    Jouvet, Anne
    Fevre-Montange, Michelle
    Ghersi-Egea, Jean-Francois
    BRAIN PATHOLOGY, 2010, 20 (05) : 926 - 935
  • [30] P-glycoprotein (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) affect brain accumulation and intestinal disposition of encorafenib in mice
    Wang, Jing
    Gan, Changpei
    Sparidans, Rolf W.
    Wagenaar, Els
    van Hoppe, Stephanie
    Beijnen, Jos H.
    Schinkel, Alfred H.
    PHARMACOLOGICAL RESEARCH, 2018, 129 : 414 - 423