Estimating glomerular filtration rate (GFR) in diabetes: The performance of MDRD and CKD-EPI equations in patients with various degrees of albuminuria

被引:34
|
作者
Lovrencic, Marijana Vucic [1 ]
Biljak, Vanja Radisic [1 ]
Bozicevic, Sandra [1 ]
Prasek, Manja [2 ]
Pavkovic, Pajica [3 ]
Knotek, Mladen [3 ]
机构
[1] Merkur Teaching Hosp, Inst Clin Chem & Lab Med, Zagreb 10000, Croatia
[2] Merkur Teaching Hosp, Vuk Vrhovac Univ Clin Diabet Endocrinol & Metab D, Zagreb 10000, Croatia
[3] Merkur Teaching Hosp, Inst Nephrol, Zagreb 10000, Croatia
关键词
Diabetes; Microalbuminuria; eGFR; MDRD; CKD-EPI; KIDNEY-FUNCTION; RENAL-DISEASE; DIET;
D O I
10.1016/j.clinbiochem.2012.07.115
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Objectives: The aim of this study was to compare the performance of Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease Study (MDRD) equations in estimating GFR in a large cohort of diabetic patients with various degrees of albuminuria. Design and methods: In a group of 842 diabetic patients GFR was estimated from standardized creatinine, with MDRD-Study and CKD-EPI equations, and their performance evaluated regarding clinical stages of albuminuria and chronic kidney disease (CKD). Results: Patients with normoalbuminuria had higher eGFR when calculated by CKD-EPI, than MDRD-Study equation [median (IQR): 103 (91-115) vs 97 (85-113) mL/min/1.73 m(2), P=0.006, n=364], which significantly influenced the prevalence of stage 1 CKD [eGFR>90 mL/min/1.73 m(2): 76.7% (CKD-EPI) vs. 65.1% (MDRD-Study), P=0.005]. There were no differences between the eGFR values derived by two equations in patients with micro- and macroalbuminuria, and more advanced staging of CKD. Conclusion: CKD-EPI equation might be a superior surrogate marker of GFR in patients with normoalbuminuria and hyperfiltration and could be used as a screening tool for early renal impairment in diabetes. It's validity as a marker of progression of diabetic nephropathy merits further investigation. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:1694 / 1696
页数:3
相关论文
共 50 条
  • [41] Estimating glomerular filtration rate in centenarians: comparison of the chronic kidney disease epidemiology collaboration (CKD-EPI) and modification of diet in renal disease (MDRD) study equations
    Basile, Giorgio
    Crucitti, Andrea
    Fusco, Sergio
    Cucinotta, Maria D.
    Maltese, Giuseppe
    Catalano, Antonino
    Lasco, Antonino
    INTERNATIONAL UROLOGY AND NEPHROLOGY, 2014, 46 (02) : 481 - 482
  • [42] Estimating glomerular filtration rate in centenarians: comparison of the chronic kidney disease epidemiology collaboration (CKD-EPI) and modification of diet in renal disease (MDRD) study equations
    Giorgio Basile
    Andrea Crucitti
    Sergio Fusco
    Maria D. Cucinotta
    Giuseppe Maltese
    Antonino Catalano
    Antonino Lasco
    International Urology and Nephrology, 2014, 46 : 481 - 482
  • [43] An Update on Reported Adoption of 2021 CKD-EPI Estimated Glomerular Filtration Rate Equations
    Genzen, Jonathan R.
    Souers, Rhona J.
    Pearson, Lauren N.
    Manthei, David M.
    Chambliss, Allison B.
    Shajani-Yi, Zahra
    Miller, W. Greg
    CLINICAL CHEMISTRY, 2023, 69 (10) : 1197 - 1199
  • [44] Comparison of Risk Prediction Using the CKD-EPI Equation and the MDRD Study Equation for Estimated Glomerular Filtration Rate
    Matsushita, Kunihiro
    Mahmoodi, Bakhtawar K.
    Woodward, Mark
    Emberson, Jonathan R.
    Jafar, Tazeen H.
    Jee, Sun Ha
    Polkinghorne, Kevan R.
    Shankar, Anoop
    Smith, David H.
    Tonelli, Marcello
    Warnock, David G.
    Wen, Chi-Pang
    Coresh, Josef
    Gansevoort, Ron T.
    Hemmelgarn, Brenda R.
    Levey, Andrew S.
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2012, 307 (18): : 1941 - 1951
  • [45] Associations of blood lead with estimated glomerular filtration rate using MDRD, CKD-EPI and serum cystatin C-based equations
    Spector, June T.
    Navas-Acien, Ana
    Fadrowski, Jeffrey
    Guallar, Eliseo
    Jaar, Bernard
    Weaver, Virginia M.
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2011, 26 (09) : 2786 - 2792
  • [46] Comparison of association of glomerular filtration rate with metabolic syndrome in a community-based population using the CKD-EPI and MDRD study equations
    Hong, Namki
    Oh, Jaewon
    Lee, Yong-ho
    Youn, Jong Chan
    Park, Sungha
    Lee, Sang-Hak
    Jang, Yangsoo
    Chung, Namsik
    Kim, Soyoon
    Jee, Sun Ha
    Kang, Seok-Min
    CLINICA CHIMICA ACTA, 2014, 429 : 157 - 162
  • [47] Comparison of MDRD, CKD-EPI, and Cockcroft-Gault equation in relation to measured glomerular filtration rate among a large cohort with diabetes
    Schwandt, Anke
    Denkinger, Michael
    Fasching, Peter
    Pfeifer, Martin
    Wagner, Christian
    Weiland, Joerg
    Zeyfang, Andrej
    Holl, Reinhard W.
    JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2017, 31 (09) : 1376 - 1383
  • [48] Comparing Results of Five Glomerular Filtration Rate-Estimating Equations in the Korean General Population: MDRD Study, Revised Lund-Malmo, and Three CKD-EPI Equations
    Ji, Misuk
    Lee, Yoon-Hee
    Hur, Mina
    Kim, Hyesun
    Cho, Han-Ik
    Yang, Hyun Suk
    Navarin, Silvia
    Di Somma, Salvatore
    ANNALS OF LABORATORY MEDICINE, 2016, 36 (06) : 521 - 528
  • [49] Estimating Glomerular Filtration Rate Using the New CKD-EPI Equation and Other Equations in Patients with Autosomal Dominant Polycystic Kidney Disease
    Orskov, Bjarne
    Borresen, Malene L.
    Feldt-Rasmussen, Bo
    Ostergaard, Ole
    Laursen, Inga
    Strandgaard, Svend
    AMERICAN JOURNAL OF NEPHROLOGY, 2010, 31 (01) : 53 - 57
  • [50] THE USE OF ABSOLUTE GLOMERULAR FILTRATION RATE VALUES IMPROVES PERFORMANCE OF CKD-EPI FORMULA
    Redal-Baigorri, Bel
    NEPHROLOGY DIALYSIS TRANSPLANTATION, 2012, 27 : 101 - 101