Recognition and Management of Medication Excipient Reactivity in Patients With Mast Cell Activation Syndrome

被引：11

作者：

Schofield, Jill R. ^{[1
,2
]}

Afrin, Lawrence B. ^{[3
]}

机构：

[1] Ctr Multisyst Dis, 8101 E Lowry Blvd, Denver, CO 80230 USA

[2] Univ Colorado, Sch Med, Aurora, CO USA

[3] Armonk Integrat Med, Armonk, NY USA

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 2019年 / 357卷 / 06期

关键词：

Excipient; Mast cell activation syndrome; Postural tachycardia syndrome; Chemical sensitivity; Ehlers-Danlos syndrome;

D O I：

10.1016/j.amjms.2019.03.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mast cell activation syndrome (MCAS) is a complex disorder hallmarked by chronic multisystem inflammatory, allergic and growth dystrophic phenomena caused by inappropriate mast cell activation. MCAS has been estimated to affect as many as 17% of the population with a severity ranging from mild to life-threatening. MCAS patients are more sensitive than the average person to chemicals in the environment, including the nondrug ("inactive") ingredients (excipients) in medications and supplements. Excipient reactivity may explain unusual side effects to medications health professionals often find puzzling, such as the patient who appears intolerant of prednisone, acetaminophen, levothyroxine, or a vitamin. We present a series of patients with MCAS to illustrate important points regarding excipient reactivity which may be useful in everyday practice.

引用

页码：507 / 511

页数：5

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