Conjugation of L-NAME to prenyloxycinnamic acids improves its inhibitory effects on nitric oxide production

被引：9
|
作者：
Genovese, Salvatore [1 ]
Epifano, Francesco [1 ]
Fiorito, Serena [1 ]
Curini, Massimo [2 ]
Marrelli, Mariangela [3 ]
Menichini, Francesco [3 ]
Conforti, Filomena [3 ]
机构：
[1] Univ G dAnnunzio, Dipartimento Farm, I-66100 Chieti, CH, Italy
[2] Univ Perugia, Dipartimento Chim & Tecnol Farmaco, I-06132 Perugia, Italy
[3] Univ Calabria, Dept Pharm & Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, CS, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 10期
关键词：
Oxyprenylated natural cinnamic acids; L-NAME; Nitric oxide; Inflammation; CANCER; SYNTHASE; SUPPRESSION; SUPEROXIDE;
D O I：
10.1016/j.bmcl.2013.03.050
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 10 compounds resulting from the conjugation of O-prenylated naturally occurring benzoic and cinnamic acids to L-NAME were synthesized and tested together with the corresponding unprenylated parent molecule as anti-inflammatory agents for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophages. Results indicated that the coupling between O-geranyl and O-isopentenylcinnamic acids and L-NAME led to products with an enhanced activity when compared to the parent compounds. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2933 / 2935
页数：3
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