Copper(I)-Catalyzed Intramolecular Direct C-Arylation of Azoles with Aryl Bromides

被引：12

作者：

Huang, Yuan ^{[1
]}

Chen, Wei ^{[1
]}

Zhao, Dan ^{[1
]}

Chen, Chen ^{[1
]}

Yin, Huiqing ^{[1
]}

Zheng, Likang ^{[1
]}

Jin, Ming ^{[1
]}

Han, Shiqing ^{[1
,2
]}

机构：

[1] Nanjing Univ Technol, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Jiangsu, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Prod, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2013年 / 31卷 / 08期

基金：

国家高技术研究发展计划(863计划);

关键词：

copper; intramolecular C-arylation; azole; aryl bromides; COPPER-CATALYZED ARYLATION; MEDIATED DIRECT ARYLATION; BOND FORMATION; FUNCTIONALIZATION; HETEROCYCLES; ACTIVATION;

D O I：

10.1002/cjoc.201300399

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A concise route to access 5H-imidazo[2,1-a]isoindole heterofused compounds by copper(I)-catalyzed intramolecular coupling of non-activated aryl bromides with azoles is reported. With CuI as catalyst, 1,10-phenanthroline as ligand, and K3PO4 as base, the reactions of 1-(2-bromobenzyl)-1H-imidazoles in DMF/o-xylene (1:1, V:V) at 145 degrees C afford the corresponding substituted 5H-imidazo[2,1-a]isoindoles in high yields via intramolecular C-arylation.

引用

页码：1007 / 1010

页数：4

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