Copper(I)-Catalyzed Intramolecular Direct C-Arylation of Azoles with Aryl Bromides

被引：12
|
作者：
Huang, Yuan [1 ]
Chen, Wei [1 ]
Zhao, Dan [1 ]
Chen, Chen [1 ]
Yin, Huiqing [1 ]
Zheng, Likang [1 ]
Jin, Ming [1 ]
Han, Shiqing [1 ,2 ]
机构：
[1] Nanjing Univ Technol, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Jiangsu, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Prod, Shanghai 200032, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2013年 / 31卷 / 08期
基金：
国家高技术研究发展计划(863计划);
关键词：
copper; intramolecular C-arylation; azole; aryl bromides; COPPER-CATALYZED ARYLATION; MEDIATED DIRECT ARYLATION; BOND FORMATION; FUNCTIONALIZATION; HETEROCYCLES; ACTIVATION;
D O I：
10.1002/cjoc.201300399
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A concise route to access 5H-imidazo[2,1-a]isoindole heterofused compounds by copper(I)-catalyzed intramolecular coupling of non-activated aryl bromides with azoles is reported. With CuI as catalyst, 1,10-phenanthroline as ligand, and K3PO4 as base, the reactions of 1-(2-bromobenzyl)-1H-imidazoles in DMF/o-xylene (1:1, V:V) at 145 degrees C afford the corresponding substituted 5H-imidazo[2,1-a]isoindoles in high yields via intramolecular C-arylation.
引用
收藏
页码：1007 / 1010
页数：4
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