Generation of induced pluripotent stem cell line (ZZUi004-A) from urine sample of a patient with spinocerebellar ataxia type 3

被引：6
|
作者：
Wang, Yanlin [1 ]
Shi, Changhe [1 ]
Wang, Zhilei [1 ]
Sun, Huifang [1 ]
Yang, Zhihua [1 ]
Zhang, Fan [2 ]
Liu, Yutao [1 ]
Liu, Han [1 ]
Jiang, Chenyang [1 ]
Zhang, Shoutao [3 ]
Xu, Yuming [1 ]
Wen, Xuejun [4 ,5 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Henan, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 2, Dept Geriatr, Zhengzhou 450014, Henan, Peoples R China
[3] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Henan, Peoples R China
[4] Virginia Commonwealth Univ, Dept Chem & Life Sci Engn, Richmond, VA 23284 USA
[5] Tongji Univ, Sch Med, Shanghai East Hosp, Inst Biomed Engn & Nano Sci, Shanghai 200120, Peoples R China
来源：
STEM CELL RESEARCH | 2018年 / 28卷
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
D O I：
10.1016/j.scr.2018.01.027
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disease caused by a CAG repeat expansion in the region of the ATXN3 gene. The main feature of SCA3 is progressive ataxia, which affects balance, gait, and speech. Urine cells (UCs) of a SCA3 patient were successfully translated to induced pluripotent stem cells (iPSCs) by using the Sendai virus delivery system. ZZUi004-A cell line may provide a robust platform for further study of SCA3 pathogenesis as well as drug testing and gene therapy research. (c) 2018 Published by Elsevier B.V.
引用
收藏
页码：71 / 74
页数：4
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