Generation of induced pluripotent stem cell line (ZZUi004-A) from urine sample of a patient with spinocerebellar ataxia type 3

被引：6

作者：

Wang, Yanlin ^{[1
]}

Shi, Changhe ^{[1
]}

Wang, Zhilei ^{[1
]}

Sun, Huifang ^{[1
]}

Yang, Zhihua ^{[1
]}

Zhang, Fan ^{[2
]}

Liu, Yutao ^{[1
]}

Liu, Han ^{[1
]}

Jiang, Chenyang ^{[1
]}

Zhang, Shoutao ^{[3
]}

Xu, Yuming ^{[1
]}

Wen, Xuejun ^{[4
,5
]}

机构：

[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou 450052, Henan, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 2, Dept Geriatr, Zhengzhou 450014, Henan, Peoples R China

[3] Zhengzhou Univ, Sch Life Sci, Zhengzhou 450001, Henan, Peoples R China

[4] Virginia Commonwealth Univ, Dept Chem & Life Sci Engn, Richmond, VA 23284 USA

[5] Tongji Univ, Sch Med, Shanghai East Hosp, Inst Biomed Engn & Nano Sci, Shanghai 200120, Peoples R China

来源：

STEM CELL RESEARCH | 2018年 / 28卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

D O I：

10.1016/j.scr.2018.01.027

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disease caused by a CAG repeat expansion in the region of the ATXN3 gene. The main feature of SCA3 is progressive ataxia, which affects balance, gait, and speech. Urine cells (UCs) of a SCA3 patient were successfully translated to induced pluripotent stem cells (iPSCs) by using the Sendai virus delivery system. ZZUi004-A cell line may provide a robust platform for further study of SCA3 pathogenesis as well as drug testing and gene therapy research. (c) 2018 Published by Elsevier B.V.

引用

页码：71 / 74

页数：4

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