What the Infectious Disease Physician Needs to Know About Pegylated Interferon and Ribavirin

被引：21
|
作者：
Gara, Naveen [1 ]
Ghany, Marc G. [1 ]
机构：
[1] NIDDKD, Liver Dis Branch, NIH, Bethesda, MD 20892 USA
来源：
CLINICAL INFECTIOUS DISEASES | 2013年 / 56卷 / 11期
基金：
美国国家卫生研究院;
关键词：
peginterferon; ribavirin; chronic hepatitis C treatment; adverse events; CHRONIC HEPATITIS-C; SUSTAINED VIROLOGICAL RESPONSE; PLACEBO-CONTROLLED TRIAL; ALPHA-2A PLUS RIBAVIRIN; CHRONIC HCV INFECTION; GENOTYPE; INFECTION; COMBINATION THERAPY; DOUBLE-BLIND; PEGINTERFERON ALPHA-2A; COINFECTED PATIENTS;
D O I：
10.1093/cid/cit074
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The treatment of chronic hepatitis C is rapidly evolving from triple therapy to regimens that do not require interferon or even ribavirin. However, pegylated interferon and ribavirin will remain the backbone of hepatitis C therapy for the time being. This review summarizes the pharmacokinetics of peginterferon and ribavirin with a particular emphasis on their side-effect profile and management. Finally, the continued role of peginterferon and ribavirin in future therapies will be discussed.
引用
收藏
页码：1629 / 1636
页数：8
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