Preparation and Application of Protein-Functionalized Magnetic Nanoparticles

Protein-functionalized magnetic nanoparticles have received considerable attention in many research areas as new functional composite materials. The stability, loading capacity and the conformation retention of the protein affect the application of the functional particles. The physicochemical properties of the surface not only affect the stability, dispersion and magnetism but also the effective loading of protein. In this paper, the surface modification of magnetic nanoparticles and the protein-functionalized methods are reviewed. Major applications of protein-functionalized magnetic nanoparticles are introduced in the field of enzymatic synthesis, detection analysis of immunoreactions, and biosensors, as well as the future developing prospects.