Convenient syntheses of dihydropyrrolo[2′,1′:3,4]pyrazino- and dihydropyrrolo[2′,1′:3,4][1,4]diazepino-[2,1-α]isoindolones

被引：24

作者：

Katritzky, AR ^{[1
]}

He, HY ^{[1
]}

Jiang, R ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(02)00350-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dihydropyrrolo[2'.1':3,4]pyrazino[2.1-a]isoindolones 10a-10c were obtained in 76-81% yields by the reaction of 2-(1H-pyrrol-l-yl)ethylamine 8 with 2-formylbenzoic acids 9a, 9b or 22-acetylbenzoic acid 9c via N-acyliminium cation aromatic cyclizations. Similarly, dihydropyrrolo[2',1':3,4][1,4]diazepino[2.1-a]isoindolones 12a, 12b were prepared in one-pot reactions front 3-(1H-pyrrol-l-yl)propylamine 11 and 2-formylbenzoic acids 9a, 9b. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2831 / 2833

页数：3

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