Indolent T- and NK-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract: Current Understanding and Outstanding Questions

被引：2
|
作者：
Soderquist, Craig [1 ]
Bhagat, Govind [1 ]
机构：
[1] Columbia Univ, Irving Med Ctr, Dept Pathol & Cell Biol, 630 West 168th St, New York, NY 10032 USA
来源：
HEMATO | 2022年 / 3卷 / 01期
关键词：
indolent; T-cell; NK-cell; lymphoproliferative disorder; gastrointestinal tract; genetics; cell of origin; LYMPHOMATOID GASTROPATHY; CLINICOPATHOLOGICAL FEATURES; MESSENGER-RNA; MEMORY CELLS; DISEASE; INTERLEUKIN-2; INTESTINE; ENTITY; GENE; MANIFESTATION;
D O I：
10.3390/hemato3010018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Indolent T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract are uncommon clonal neoplasms that have a protracted clinical course and limited response to therapy. In recent years, advances in the immunophenotypic, genetic, and clinical characterization of these disorders have led to increased awareness and a better understanding of disease pathogenesis. However, many questions remain unanswered, including those concerning the cell(s) of origin, inciting immune or environmental factors, and the molecular pathways underlying disease progression and transformation. In this review, we discuss recent findings regarding the immunophenotypic and genomic spectrum of these lymphoproliferative disorders and highlight unresolved issues.
引用
收藏
页码：219 / 231
页数：13
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