Copper-Catalyzed C-O Bond Formation: An Efficient One-Pot Highly Regioselective Synthesis of Furans from (2-Furyl)Carbene Complexes

被引：122

作者：

Cao, Hua ^{[1
]}

Zhan, Haiying ^{[1
]}

Cen, Jinghe ^{[1
]}

Lin, Jingxin ^{[1
]}

Lin, Yuanguang ^{[1
]}

Zhu, Qiuxia ^{[1
]}

Fu, Minling ^{[1
]}

Jiang, Huanfeng ^{[2
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China

[2] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 05期

关键词：

FISCHER CARBENE COMPLEXES; ELECTRON-DEFICIENT ALKYNES; 2,3-ALLENOIC ACIDS; DOMINO PROCESS; 2,5-DISUBSTITUTED FURANS; POLYSUBSTITUTED FURANS; BIOLOGICAL EVALUATION; CYCLIZATION REACTION; KETONES; DERIVATIVES;

D O I：

10.1021/ol400080e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient one-pot Cu(I)-catalyzed strategy for regioselective synthesis of trisubstituted furan derivatives has been developed via (2-furyl) carbene complexes. This process has opened a new synthetic route to a variety of alpha-carbonyl furans using air as the oxidant affording furans in good yields.

引用

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页码：1080 / 1083

页数：4

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