Synthesis of spermidine and norspermidine dimers as high affinity polyamine transport inhibitors

被引：26

作者：

Covassin, L

Desjardins, M

Charest-Gaudreault, R

Audette, M

Bonneau, MJ

Poulin, R ^{[1
]}

机构：

[1] Univ Laval, Fac Med, Dept Physiol, Quebec City, PQ G1K 7P4, Canada

[2] Univ Laval, Fac Pharm, Quebec City, PQ G1K 7P4, Canada

[3] Univ Laval, Fac Med, Dept Pharmacol, Quebec City, PQ G1K 7P4, Canada

[4] Univ Laval, Fac Med, Dept Med Biol, Quebec City, PQ G1K 7P4, Canada

[5] CHUQ, St Francois Assise Hosp, Res Ctr, Quebec City, PQ G1L 3L5, Canada

[6] Univ Laval, Med Res Ctr, CHUQ, Mol Endocrinol Lab, Quebec City, PQ G1V 4G2, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(99)00262-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel spermidine and sym-norspermidine dimers was synthesized by crosslinking the polyamine backbones via alkylation of their secondary amino groups to butyl, trans-2-butenyl, 2-butynyl or p-xylyl bridges. The resulting hexamines behaved as high-affinity antagonists of polyamine uptake, with a relative potency that was dependent on the geometry of the linker structure. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1709 / 1714

页数：6

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