A Facile Synthesis of Pyrido[2′,3′:3,4] pyrazolo[1,5-a] pyrimidine and Pyrido[2′,3′:3,4] pyrazolo[5,1-c][1,2,4] triazine Bearing a Thiophene Moiety

被引：6

作者：

Elsaman, Tilal ^{[1
]}

Fares, Mohamed ^{[2
]}

Abdel-Aziz, Hatem A. ^{[1
,3
]}

Attia, Mohamed I. ^{[1
,4
]}

Ghabbour, Hazem A. ^{[1
]}

Dawood, Kamal M. ^{[5
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Riyadh 11451, Saudi Arabia

[2] Egyptian Russian Univ, Dept Pharmaceut Chem, Coll Pharm, Badr City 11829, Cairo, Egypt

[3] Natl Res Ctr, Dept Appl Organ Chem, Giza 12622, Egypt

[4] Natl Res Ctr, Dept Med & Pharmaceut Chem, Pharmaceut & Drug Ind Res Div, Giza 12622, Egypt

[5] Cairo Univ, Dept Chem, Fac Sci, Giza 12613, Egypt

来源：

JOURNAL OF CHEMISTRY | 2013年 / 2013卷

关键词：

DERIVATIVES; ANALOGS;

D O I：

10.1155/2013/463515

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pyridinone derivative 8 was synthesized and transformed into the respective chloropyridine 9, which was allowed to react with hydrazine hydrate to afford pyrazolo[3,4-b] pyridin-3-amine derivative 11. Compound 11 was used as a key intermediate for a facile synthesis of the title compounds 14, 15, 17, 21a, b, and 24a-c where the reaction of 11 with some 1,3-dielecrophiles resulted in the formation of pyrido[2',3' : 3,4] pyrazolo[1,5-a] pyrimidines 14, 15, and 17, whereas diazotization of compound 11 gave the respective diazonium salt 18 which was coupled with some active methylene-containing compounds to give the corresponding hydrazones 19a, b and 22a-c. Cyclization of the latter hydrazones yielded the pyrido[2',3' : 3,4] pyrazolo[5,1-c][1,2,4] triazines 21a, b and 24a-c, respectively.

引用

页数：7

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