Targeting Notch and Hedgehog Embryonic Signaling Pathways Has Potent Anti-Tumor Activity in Myeloma and Is Effective in Myeloma Bone Disease.

被引：0
|
作者：
Schwarzer, Rolf [1 ]
Schuenemann, Nicole [1 ]
Wong, David M. [2 ]
Bogen, Bjarne [3 ,4 ]
Bommert, Kurt [5 ]
Doerken, Bernd [1 ]
Manz, Rudolf [2 ]
Jundt, Franziska [1 ]
机构：
[1] Univ Med Berlin, Charite, Dept Hematol & Oncol, Berlin, Germany
[2] Med Univ Lubeck, Inst Syst Inflammat Res, D-23538 Lubeck, Germany
[3] Univ Oslo, Dept Immunol & Transfus Med, Ctr Immune Regulat, Oslo, Norway
[4] Oslo Univ Hosp, Oslo, Norway
[5] Univ Wurzburg, Med Ctr, D-97070 Wurzburg, Germany
来源：
BLOOD | 2012年 / 120卷 / 21期
关键词：
D O I：
10.1182/blood.V120.21.2938.2938
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
2938
引用
收藏
页数：2
相关论文
共 46 条
  • [21] Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma
    Taiana, Elisa
    Favasuli, Vanessa
    Ronchetti, Domenica
    Todoerti, Katia
    Pelizzoni, Francesca
    Manzoni, Martina
    Barbieri, Marzia
    Fabris, Sonia
    Silvestris, Ilaria
    Cantafio, Maria Eugenia Gallo
    Platonova, Natalia
    Zuccala, Valeria
    Maltese, Lorenza
    Soncini, Debora
    Ruberti, Samantha
    Cea, Michele
    Chiaramonte, Raffaella
    Amodio, Nicola
    Tassone, Pierfrancesco
    Agnelli, Luca
    Neri, Antonino
    [J]. LEUKEMIA, 2020, 34 (01) : 234 - 244
  • [22] THE NOVEL HDAC INHIBITOR UCL67022 HAS POTENT ACTIVITY IN MULTIPLE MYELOMA CELLS AND REMAINS EFFECTIVE IN A BONE MARROW MICRO-ENVIRONMENT MODEL
    Popat, R.
    Maharaj, L.
    Oakervee, H.
    Cavenagh, J.
    Middleton, B.
    Rioja, A.
    Marson, C.
    Joel, S.
    [J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 115 - 115
  • [23] Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma
    Elisa Taiana
    Vanessa Favasuli
    Domenica Ronchetti
    Katia Todoerti
    Francesca Pelizzoni
    Martina Manzoni
    Marzia Barbieri
    Sonia Fabris
    Ilaria Silvestris
    Maria Eugenia Gallo Cantafio
    Natalia Platonova
    Valeria Zuccalà
    Lorenza Maltese
    Debora Soncini
    Samantha Ruberti
    Michele Cea
    Raffaella Chiaramonte
    Nicola Amodio
    Pierfrancesco Tassone
    Luca Agnelli
    Antonino Neri
    [J]. Leukemia, 2020, 34 : 234 - 244
  • [24] A novel topoisomerase I inhibitor antibody-drug conjugate targeting CEACAM5 has potent anti-tumor activity in colorectal cancer models
    Baudat, Yves
    Neff-LaFord, Haley
    Nicolazzi, Celine
    Meyer, Dave
    Sigurjonsson, Johann Petur
    Lyski, Ryan
    Fantin, Valeria
    Brun, Marie-Priscille
    Chiron, Marielle
    Decary, Stephanie
    [J]. CANCER RESEARCH, 2023, 83 (07)
  • [25] CARFILZOMIB: A SELECTIVE INHIBITOR OF THE CHYMOTRYPSIN-LIKE ACTIVITY OF THE CONSTITUTIVE PROTESOME AND IMMUNOPROTEASOME HAS ANTI-TUMOR ACTIVITY ON MULTIPLE MYELOMA, LYMPHOMA AND LEUKEMIA CELLS WITH MINIMAL EFFECTS ON NORMAL CELLS
    Parlati, F.
    Lee, S.
    Aujay, M.
    Levitsky, K.
    Lorens, J.
    Lu, Y.
    Micklem, D.
    Rurrs, P.
    Shenk, K.
    Sun, C.
    Suzuki, E.
    Sylvain, C.
    Bennett, M. K.
    [J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2009, 94 : 148 - 149
  • [26] A Humanized Anti-Ganglioside GM2 Antibody, BIW-8962, Exhibits ADCC/CDC Activity against Multiple Myeloma Cells and Potent Anti-Tumor Activity in Mouse Xenograft Models
    Ishi, Toshihiko
    Chanan-Khan, Asher Alban
    Jafferjee, Jazur
    Ersing, Noreen
    Takahashi, Takeshi
    Mizutani, Masato
    Shiotsu, Yukimasa
    Hanai, Nobuo
    [J]. BLOOD, 2008, 112 (11) : 605 - 605
  • [27] P-BCMA-ALLO1-A Fully Allogeneic Stem Cell Memory T Cell (TSCM) CAR-T Therapy Targeting BCMA for the Treatment of Multiple Myeloma Shows Potent Anti-Tumor Activity
    Richter, Maximilian
    Cranert, Stacey
    Patil, Deepak
    Zhang, Yan
    Tan, Yening
    Tong, Min
    Domingo, Christine
    Weiss, Leslie
    Marquez, Karl
    Sparks, Jessica
    Argus, Elvira
    Martin, Christopher
    Ostertag, Eric
    Jain, Sumiti
    Coronella, Julia
    Shedlock, Devon
    [J]. MOLECULAR THERAPY, 2021, 29 (04) : 382 - 383
  • [28] Combination therapy based on a bone-targeted Notch inhibitor and anti-Sclerostin antibody simultaneously decreases tumor burden and rebuilds damaged bone in mice with established myeloma disease
    Sabol, Hayley M.
    Adhikari, Manish
    Anloague, Aric
    Khan, Sharmin
    Srinivasan, Venkatesan
    Frontier, Alison
    Ebetino, Frank H.
    Delgado-Calle, Jesus
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 57 - 57
  • [29] BT5528, a Bicycle Toxin Conjugate targeting EphA2 has potent anti-tumor activity without bleeding or coagulation abnormalities in preclinical models
    Bennett, Gavin
    Huxley, Philip
    Brown, Amy
    Mudd, Gemma
    Park, Peter U.
    Keen, Nicholas
    [J]. CANCER RESEARCH, 2018, 78 (13)
  • [30] High expansion level and long term persistence of BCMA CAR-T cells contribute to potent anti-tumor activity against heavily treated multiple myeloma patients
    Hu, Yongxian
    Zhang, Yanlei
    Wei, Guoqing
    Xu, Huijun
    Wu, Wenjun
    Liu, Shaohui
    Cui, Jiazhen
    Chang, Alex Hongsheng
    Huang, He
    [J]. BONE MARROW TRANSPLANTATION, 2019, 54 : 37 - 38
12345