No significant prognostic value of normal precursor B-cell regeneration in paediatric acute myeloid leukaemia after induction treatment

被引：6
|
作者：
Bras, Anne E. [1 ,2 ]
van den Heuvel-Eibrink, Marry M. [2 ]
van der Sluijs-Gelling, Alita J. [3 ]
Coenen, Eva A. [2 ]
Wind, Henk [1 ]
Zwaan, C. Michel [2 ,3 ]
te Marvel-de, Jeroen G. [1 ]
van der Burg, Mirjam [1 ]
Gibson, Brenda [4 ]
Rijneveld, Anita W. [5 ]
de Haas, Valerie [3 ]
van Dongen, Jacques J. M. [1 ]
van der Velden, Vincent H. J. [1 ]
机构：
[1] Erasmus MC, Dept Immunol, Univ Med Ctr Rotterdam, NL-3015 GE Rotterdam, Netherlands
[2] Erasmus MC, Dept Paediat Oncol Haematol, NL-3015 GE Rotterdam, Netherlands
[3] Dutch Childhood Oncol Grp, The Hague, Netherlands
[4] Royal Hosp Sick Children, Glasgow G3 8SJ, Lanark, Scotland
[5] Erasmus MC, Dept Haematol, Univ Med Ctr Rotterdam, NL-3015 GE Rotterdam, Netherlands
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2013年 / 161卷 / 06期
关键词：
paediatric; AML; B-cells; MRD; relapse; BONE-MARROW; TRIAL;
D O I：
10.1111/bjh.12329
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
B-cell precursors (BCP) regeneration in bone marrow (BM) after induction chemotherapy is prognostic for good treatment response in adult acute myeloid leukaemia (AML). We detected BCP regeneration in 81% of 59 paediatric AML patients at first complete remission; this compared to 46% in an adult study. BCP regeneration did not correlate with outcome or minimal residual disease levels. In 36 healthy BM controls, BCP levels were significantly higher in children as compared to adults. Therefore, BCP regeneration does not reflect good response to treatment in paediatric AML, possibly due to the relatively high base-line levels of BCP in children.
引用
收藏
页码：861 / 864
页数：4
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