Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters

被引：11
|
作者：
Pascual, Iranzu [1 ]
Larrayoz, Ignacio M. [1 ]
Rodriguez, Ignacio R. [1 ]
机构：
[1] NEI, NIH, Retinal Cell & Mol Biol Lab, Mech Retinal Dis Sect, Bethesda, MD 20892 USA
来源：
GENOMICS | 2009年 / 93卷 / 01期
关键词：
Methionine sulfoxide reductase; Dual promoters; Retinoic acid; Retinoic acid receptors; Promoters; Regulatory elements; RPE; OXIDATIVE STRESS; SACCHAROMYCES-CEREVISIAE; A MSRA; CELLS; EXPRESSION; MITOCHONDRIAL; PROTEINS; PROTECTS; MAMMALS; CLONING;
D O I：
10.1016/j.ygeno.2008.09.002
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
MSRAs (methionine sulfoxide reductases A) are enzymes that reverse the effects of oxidative damage by reducing methionine sulfoxide back to methionine and recovering protein function. In this study we demonstrate that the transcriptional regulation of the human MSRA gene is complex and driven by two distinct promoters. Both promoters demonstrate high expression in human brain and kidney tissues. The upstream (promoter I) regulates the msrA1 transcript that codes for the mitochondrial form of MSRA and is highly active in a broad range of cell lines. The downstream promoter (promoter 2) regulates the msrA2/3 transcripts that code for the cytosolic/nuclear forms of MSRA and is generally less active. Promoter 2 contains a 65 bp putative enhancer region that is very active in the retinal pigment epithelium-derived D407 cell line. Both promoters are partially regulated by all-trans retinoic acid via RARA and other RARs. Published by Elsevier Inc.
引用
收藏
页码：62 / 71
页数：10
相关论文
共 50 条
  • [31] Acceleration of thrombomodulin gene transcription by retinoic acid -: Retinoic acid receptors and Sp1 regulate the promoter activity through interactions with two different sequences in the 5′-flanking region of human gene
    Horie, S
    Ishii, H
    Matsumoto, F
    Kusano, M
    Kizaki, K
    Matsuda, J
    Kazama, M
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (04) : 2440 - 2450
  • [32] 9-cis-retinoic acid represses transcription of the gonadotropin-releasing hormone (GnRH) gene via proximal promoter region that is distinct from all-trans-retinoic acid response element
    Cho, S
    Chung, JJ
    Han, J
    Lee, BJ
    Kim, DH
    Rhee, K
    Kim, K
    MOLECULAR BRAIN RESEARCH, 2001, 87 (02): : 214 - 222
  • [33] All-trans retinoic acid down-regulates human albumin gene expression through the induction of C/EBPβ-LIP
    Masaki, Takahiro
    Matsuura, Tomokazu
    Ohkawa, Kiyoshi
    Miyamura, Tatsuo
    Okazaki, Isao
    Watanabe, Tetsu
    Suzuki, Tetsuro
    BIOCHEMICAL JOURNAL, 2006, 397 (345-353) : 345 - 353
  • [34] Abscisic acid-dependent nitric oxide pathway and abscisic acid-independent nitric oxide routes differently modulate NaCl stress induction of the gene expression of methionine sulfoxide reductase A and B in rice roots
    Hsu, Yi Ting
    Lee, Tse-Min
    JOURNAL OF PLANT PHYSIOLOGY, 2018, 231 : 374 - 382
  • [35] Retinoic acid-inducible gene-I is induced by double stranded RNA and regulates the expression of CCL 5 in human mesangial cells
    Tanaka, H.
    Aizawa-Yashiro, T.
    Tsugawa, K.
    Oki, E.
    Imaizumi, T.
    PEDIATRIC NEPHROLOGY, 2011, 26 (05) : 827 - 827
  • [36] Effect of methionine sulfoxide reductase B1 (Se1R) gene silencing on peroxynitrite-induced F-actin disruption in human lens epithelial cells
    Jia, Yi
    Zhou, Jun
    Liu, Hongmei
    Huang, Kaixun
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2014, 443 (03) : 876 - 881
  • [37] Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes
    Richards, JA
    Brueggemeier, RW
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (06): : 2810 - 2816
  • [38] THE MEK/ERK PATHWAY BUT NOT P38MAPK PROMOTES CHROMATIN REMODELING AT RETINOIC ACID TARGET GENE PROMOTERS AND POTENTIATES GRANULOCYTIC DIFFERENTIATION VIA RAR ALPHA RECRUITMENT
    Cassinat, B.
    Zassadowski, F.
    Ferry, C.
    Llopis, L.
    Bruck, N.
    Lainey, E.
    Duong, V.
    Despouy, G.
    Fenaux, P.
    Rochette-Egly, C.
    Chomienne, C.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 : 33 - 33
  • [39] Mutational analysis of human thioredoxin reductase 1 - Effects on p53-mediated gene expression and interferon and retinoic acid-induced cell death
    Ma, XR
    Hu, JB
    Lindner, DJ
    Kalvakolanu, DV
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (25) : 22460 - 22468
  • [40] Characterization of the human mineralocorticoid receptor gene 5'-regulatory region: Evidence for differential hormonal regulation of two alternative promoters via nonclassical mechanisms
    Zennaro, MC
    Le Menuet, D
    Lombes, M
    MOLECULAR ENDOCRINOLOGY, 1996, 10 (12) : 1549 - 1560
12345