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Sun Yat Sen Univ, Guangdong Key Lab Pharmaceut Funct Genes, MOE Key Lab Gene Funct & Regulat, State Key Lab Biocontrol,Sch Life Sci,Dept Bioche, 56 Lingyuan West Rd, Guangzhou 510055, Peoples R China Sun Yat Sen Univ, Guangdong Prov Key Lab Stomatol, Guanghua Sch Stomatol, Dept Oral & Maxillofacial Surg, 56 Lingyuan West Rd, Guangzhou 510055, Peoples R China