Relationship between blood homocysteine and creatinine in patients with metabolic syndrome and association between hyperhomocysteinemia and metabolic syndrome

The aims were to determine a possible relationship between homocysteine and creatinine and between hyperhomocysteinemia and metabolic syndrome. Patients and methods. The study enrolled 77 patients with metabolic syndrome. They benefit from clinical examination and biological tests and were divided into two groups: group 1 (homocysteine < 15 mu mol/l) and group 2 (homocysteine >= 15 ilmol/l). Results. The mean age, homocysteinemia and creatininennia were respectively: 53.11 +/- 8.80 years, 12.55 +/- 3.47 mu mol/l and 73.73 +/- 17.31 mu mol/l . The mean age and creatininemia were significantly higher in group 2 than in group 1, respectively: 56.88 +/- 10.966 years vs. 51.84 +/- 8.094 years, p<0.05 and 85.24 +/- 23.88 mu mol/l vs. 70.02 +/- 13.602 p=0.021. A significant correlation was found between homocysteinemia and metabolic syndrome criteria number (p=0.009). Conclusion. The homocysteine increases proportionally with the age, blood creatininemia and severity of the metabolic syndrome. (C) 2011 Elsevier Masson SAS. All rights reserved.