Structural probing of Zn(II), Cd(II) and Hg(II) binding to human ubiquitin

被引：25

作者：

Falini, Giuseppe ^{[1
]}

Fermani, Simona ^{[1
]}

Tosi, Giovanna ^{[1
]}

Arnesano, Fabio ^{[2
]}

Natile, Giovanni ^{[2
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

[2] Univ Bari A Moro, Dipartimento Farmacochim, I-70125 Bari, Italy

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 45期

关键词：

D O I：

10.1039/b813463d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A structural investigation performed on adducts of human ubiquitin with group-12 metal ions reveals common preferential anchoring sites, the most populated one being His68; at higher metal ion concentration a second and a third site, close to the N-terminus of the protein, become populated and promote a polymorphic transition from orthorhombic to cubic form; Glu16 and Glu18, involved in the latter metal binding, undergo a remarkable displacement from their position in native ubiquitin; the aggregate stereochemistry appears to be driven by the clustering of deshielded backbone hydrogen-bond patches, and metal ions foster this process.

引用

页码：5960 / 5962

页数：3

共 50 条

[31] EXTRACTION OF ZN(II), CD(II), AND HG(II) BY DODECYLOLIGO(OXYETHYLENE) CARBOXYLIC-ACIDS
STRZELBICKI, J
CHAREWICZ, W
BEGER, J
HINZ, L
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1988, 66 (07): : 1695 - 1700
[32] COMPLEXES OF BIS(O-AMINOBENZENESULFONYL) ETHYLENEDIAMINE WITH ZN(II), CD(II) AND HG(II)
PERLEPES, SP
ZAFIROPOULOS, TF
GALINOS, AG
TSANGARIS, JM
CHEMICA SCRIPTA, 1983, 22 (05): : 226 - 229
[33] Redox switched fluorescent probe service for either Hg(II) or Cd(II) and Zn(II)
Hennrich, Gunther
Sonnenschein, Helmut
Resch-Genger, Ute
Journal of the American Chemical Society, 1999, 121 (21):
[34] MORPHOLINE-4-CARBODITHIOATE AS A GRAVIMETRIC REAGENT FOR ZN(II) CD(II) AND HG(II)
SINGH, N
KULSHRESTHA, SK
AGARWAL, AK
SRIVASTAVA, TN
CURRENT SCIENCE, 1979, 48 (05): : 204 - 206
[35] Synthesis, characterization and hypoglycemic activity of Zn(II), Cd(II) and Hg(II) complexes with glibenclamide
Rasheed, Khalid
Tariq, Muhammad Ilyas
Munir, Christy
Hussain, Ishtiaq
Siddiqui, Hamid Latif
CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (02) : 168 - 172
[36] Coordination compounds of dimethylethyleneurea with Zn(II), Cd(II) and Hg(II): Synthesis, characterization and thermochemistry
deFarias, RF
deOliveira, OA
QUIMICA NOVA, 1996, 19 (02): : 100 - 104
[37] Redox switchable fluorescent probe selective for either Hg(II) or Cd(II) and Zn(II)
Hennrich, G
Sonnenschein, H
Resch-Genger, U
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (21) : 5073 - 5074
[38] Coordination of Zn(II), Cd(II), Hg(II), and Ag(I) by bis(benzimidazole) ligands
Matthews, CJ
Clegg, W
Heath, SL
Martin, NC
Hill, MNS
Lockhart, JC
INORGANIC CHEMISTRY, 1998, 37 (02) : 199 - 207
[39] ANION-EXCHANGE SELECTIVITIES OF ZN(II), CD(II), HG(II) AND BA(II) IN KI SOLUTIONS
NASIR, MI
MAHAN, A
INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY, 1992, 31 (04): : 285 - 287
[40] 1,3,8-TRIMETHYLXANTHINE COMPLEXES OF CU(II), ZN(II), CD(II), AND HG(II)
COLACIORODRIGUEZ, E
LOPEZGONZALEZ, JD
SALASPEREGRIN, JM
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1983, 61 (11): : 2506 - 2508

← 1 2 3 4 5 →