Loss of 22q chromosome is related to glioma progression and loss of 10q

被引：10
|
作者：
Laigle-Donadey, F
Crinière, E
Benouaich, A
Lesueur, E
Mokhtari, K
Hoang-Xuan, K
Sanson, M
机构：
[1] Grp Hosp Pitie Salpetriere, Federat Neurol Mazarin, F-75013 Paris, France
[2] Univ Paris 06, INSERM, U711, UMR, F-75252 Paris 05, France
[3] Univ Paris 06, Grp Hosp Pitie Salpetriere, Neuropathol Lab, F-75252 Paris 05, France
来源：
JOURNAL OF NEURO-ONCOLOGY | 2006年 / 76卷 / 03期
关键词：
chromosome; 10q; 22q; glioma;
D O I：
10.1007/s11060-005-7019-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Loss of heterozygosity (LOH) of chromosome 22q has been investigated in 160 gliomas. LOH at one or more microsatellite increased with increasing grade of the tumor (P < 0.01). LOH22q was more frequent in astrocytic tumors (37%) compared to mixed or oligodendroglial tumors (21%) (P = 0.02). LOH22q was correlated to 10q loss but not to 1p or 9p loss. Taken together, these data suggest that LOH22q is an alteration associated with malignant progression of gliomas.
引用
收藏
页码：265 / 268
页数：4
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