Polymorphisms of Intron 1 and the Promoter Region at the PRNP Gene in BSE-Free Caracu Cattle

被引：6

作者：

Galvao, Cleber Eduardo ^{[2
]}

Soares Rosinha, Gracia Maria ^{[1
]}

Sanches, Cristiane Camargo ^{[2
]}

Elisei, Carina ^{[1
]}

Araujo, Flabio Ribeiro ^{[3
]}

Dias Feijo, Gelson Luis ^{[4
]}

de Almeida Torres, Roberto Augusto, Jr. ^{[5
]}

Soares, Cleber Oliveira ^{[1
]}

机构：

[1] Embrapa Gado de Corte, Sanidade Anim, Lab Engn Genet Anim, Campo Grande, MS, Brazil

[2] Univ Fed Mato Grosso do Sul, Programa Posgrad Mestrado Ciencia Anim, Campo Grande, MS, Brazil

[3] Embrapa Gado de Corte, Sanidade Anim, Lab Imunol, Campo Grande, MS, Brazil

[4] Embrapa Gado de Corte, Manejo & Prod Anim, Campo Grande, MS, Brazil

[5] Embrapa Gado de Corte, Melhoramento Anim, Campo Grande, MS, Brazil

来源：

BIOCHEMICAL GENETICS | 2012年 / 50卷 / 9-10期

关键词：

Bovine spongiform encephalopathy; PRNP; Prion; Indel; Caracu cattle; PRION PROTEIN GENE; BOVINE SPONGIFORM ENCEPHALOPATHY; GERMAN CATTLE; DAIRY-CATTLE; SUSCEPTIBILITY; HOLSTEIN; ASSOCIATION; FREQUENCIES; EXPRESSION; DNA;

D O I：

10.1007/s10528-012-9508-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The infectious prion protein PrPSc is encoded by the PRNP gene. In cattle, insertion/deletion (indel) polymorphisms are among the changes that occur in this gene, the most studied of which are within intron 1 (12 bp) and the promoter region (23 bp). Sequence variants in this gene may affect the formation of PrPSc. In the present study, nucleotide variability in specific regions of the PRNP gene in Caracu cattle free of bovine spongiform encephalopathy was investigated to determine the genotypic profile of each animal within the group. Caracu cattle exhibited high allele frequency for the two polymorphic regions studied, 12ins (70 %) and 23ins (72.5 %), genotype frequencies of 50 % for 12ins/ins and 50 % for 23ins/del, and a high frequency of the 12ins-23ins haplotype (57.5 %). Of the 40 animals sampled, 15 had the 12ins-23ins/12ins-23ins diplotype.

引用

页码：657 / 669

页数：13

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