Cullens sign following ultrasound-guided transvaginal oocyte retrieval

Objective: To describe two cases of periumbilical hematoma (Cullens sign) following ultrasound-guided transvaginal oocyte retrieval. Design: Case report. Setting: University-affiliated teaching hospital. Patient(s): Two patients, 34 and 32 years old, who developed Cullens sign following ultrasound-guided transvaginal oocyte retrieval. Intervention(s): Workup for pancreatitis and coagulopathies. Laparoscopy was preformed in one patient. Main Outcome Measure(s): Resolution of the symptoms. Result(s): Pancreatitis, coagulopathy, and massive hemoperitoneum were ruled out. Symptoms resided within two weeks. Conclusion(s): The appearance of a periumbilical hematoma (Cullens sign) following ultrasound-guided transvaginal oocyte retrieval reflects a retroperitoneal hematoma of a benign course.