A Review of the Secondary Metabolites From the Marine Sponges of the Genus Aaptos

被引：17
|
作者：
He, Qianqian [1 ,2 ]
Miao, Shuang [1 ]
Ni, Na [3 ]
Man, Yuqing [2 ]
Gong, Kaikai [1 ]
机构：
[1] Binzhou Med Univ Hosp, Canc Res Inst, Yellow River Second Rd 661, Binzhou 256600, Shandong, Peoples R China
[2] Binzhou Med Univ Hosp, Dept Pharm, Yellow River Second Rd 661, Binzhou 256600, Shandong, Peoples R China
[3] Binzhou Med Univ Hosp, Clin Med Lab, Binzhou, Shandong, Peoples R China
来源：
NATURAL PRODUCT COMMUNICATIONS | 2020年 / 15卷 / 09期
基金：
中国国家自然科学基金;
关键词：
marine sponge; Aaptos; secondary metabolites; bioactivity; alkaloids; AAPTAMINE DERIVATIVES; NATURAL-PRODUCTS; ALKALOIDS; HADROMERIDA;
D O I：
10.1177/1934578X20951439
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Marine sponges, which belong to the phylum Porifera (Metazoa), are considered the single best source of marine natural products. Among them, members of the genus Aaptos are attractive targets for marine natural product research owing to their abundant biogenetic ability to produce aaptamine derivatives. Apart from aaptamine alkaloids, there are also reports of other compounds from Aaptos sponges. This work reviews the secondary metabolites isolated from Aaptos species from 1982 to 2020, with 46 citations referring to 62 compounds (47 for aaptamines and 15 for others). The emphasis is placed on the structure of the organic molecules, relevant biological activities, chemical ecology aspects, and biosynthesis studies, which are described in the classifications of aaptamines and other compounds in the order of the published year.
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收藏
页数：12
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