In this issue of Blood, Karschnia et al spotlight the "Achilles heel" of chimeric antigen receptor (CAR) T-cell therapy and call for prospective clinical trials to evaluate strategies to manage and potentially prevent CAR T cell-induced neurotoxicity (NT).(1)
机构:
Harvard Med Sch, Blavatnik Inst, Dept Immunol, Boston, MA 02115 USA
Harvard Med Sch, Evergrande Ctr Immunol Dis, Boston, MA 02115 USA
Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
Broad Inst MIT & Harvard, Cambridge, MA 02142 USAHarvard Med Sch, Blavatnik Inst, Dept Immunol, Boston, MA 02115 USA
LaFleur, Martin W.
Miller, Brian C.
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机构:
Harvard Med Sch, Blavatnik Inst, Dept Immunol, Boston, MA 02115 USA
Harvard Med Sch, Evergrande Ctr Immunol Dis, Boston, MA 02115 USA
Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USAHarvard Med Sch, Blavatnik Inst, Dept Immunol, Boston, MA 02115 USA
Miller, Brian C.
Sharpe, Arlene H.
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机构:
Harvard Med Sch, Blavatnik Inst, Dept Immunol, Boston, MA 02115 USA
Harvard Med Sch, Evergrande Ctr Immunol Dis, Boston, MA 02115 USA
Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
Broad Inst MIT & Harvard, Cambridge, MA 02142 USAHarvard Med Sch, Blavatnik Inst, Dept Immunol, Boston, MA 02115 USA
机构:
Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Zhigang Liu
Ting Niu
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Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Ting Niu
Chuan He
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Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
Chuan He
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机构:
Ying Qu
Zhiyong Qian
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Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University
机构:Sichuan Univ, West China Hosp, Dept Hematol, Chengdu 610041, Peoples R China
Zeng, Qiang
Liu, Zhigang
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机构:Sichuan Univ, West China Hosp, Dept Hematol, Chengdu 610041, Peoples R China
Liu, Zhigang
Niu, Ting
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机构:Sichuan Univ, West China Hosp, Dept Hematol, Chengdu 610041, Peoples R China
Niu, Ting
He, Chuan
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机构:Sichuan Univ, West China Hosp, Dept Hematol, Chengdu 610041, Peoples R China
He, Chuan
Qu, Ying
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机构:
Sichuan Univ, West China Hosp, Dept Hematol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Hematol, Chengdu 610041, Peoples R China
Qu, Ying
Qian, Zhiyong
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Sichuan Univ, West China Hosp, Dept Hematol, Chengdu 610041, Peoples R ChinaSichuan Univ, West China Hosp, Dept Hematol, Chengdu 610041, Peoples R China
机构:
Kings Coll London, Div Canc Studies, ImmunoEngn Grp, London SE1 9RT, EnglandKings Coll London, Div Canc Studies, ImmunoEngn Grp, London SE1 9RT, England
Emami-Shahri, Nia
Papa, Sophie
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机构:
Kings Coll London, Div Canc Studies, ImmunoEngn Grp, London SE1 9RT, England
Guys & St Thomas NHS Fdn Trust, Dept Med Oncol, London SE1 9RT, EnglandKings Coll London, Div Canc Studies, ImmunoEngn Grp, London SE1 9RT, England