Factor V Leiden mutation in venous thrombosis in southeast Turkey

被引：13
|
作者：
Kalkanli, S [1 ]
Ayyildiz, O
Tiftik, N
Batun, S
Isikdogan, A
Ince, H
Tekes, S
Muftuoglu, E
机构：
[1] Dicle Univ, Dept Med Genet Biol, TR-21280 Diyarbakir, Turkey
[2] Dicle Univ, Dept Hematol Oncol, TR-21280 Diyarbakir, Turkey
来源：
ANGIOLOGY | 2006年 / 57卷 / 02期
关键词：
D O I：
10.1177/000331970605700209
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Venous thrombosis (VT) is a common disease, with an annual incidence in the general population of approximately I per 1,000. Factor V Leiden mutation (G1691A) (FVL) is the most common risk factor in venous thrombosis. The prevalence of FVL for thrombosis varies greatly in different regions of the world. FVL mutation has been identified both by conventional method and fluorescence resonance energy transfer (FRET) with the LightCycler. Sixty-one patients with VT, different in age and sex, were consecutively entered into this study to assess the prevalence of FVL in VT in southeast Turkey. FVL mutation was found in 24.6% (15/61). Fourteen individuals were heterozygous and I homozygous, a rate of 22.9% and 1.6%, respectively. In conclusion, the authors suggest that FVL mutation is common in patients with venous thrombosis in southeast Turkey.
引用
收藏
页码：193 / 196
页数：4
相关论文
共 50 条
  • [21] ASSOCIATION BETWEEN FACTOR V LEIDEN MUTATION AND CEREBRAL VENOUS THROMBOSIS IN WESTERN IRAN
    Rahimi, Z.
    Mozafari, H.
    Bigvand, A. Amiri
    Doulabi, R. Mohammad
    Razazian, N.
    Afshari, D.
    Rezaei, M.
    [J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 344 - 344
  • [22] Bilateral renal vein thrombosis and venous sinus thrombosis in a neonate with factor V mutation (FV Leiden)
    Pohl, M
    Zimmerhackl, LB
    Heinen, F
    Sutor, AH
    Schneppenheim, R
    Brandis, M
    [J]. JOURNAL OF PEDIATRICS, 1998, 132 (01): : 159 - 161
  • [23] Factor V Leiden and venous thrombosis in Danish centenarians
    Kristensen, SR
    Andersen-Ranberg, K
    Bathum, L
    Jeune, B
    [J]. THROMBOSIS AND HAEMOSTASIS, 1998, 80 (05) : 860 - 861
  • [24] UNEXPLAINED THROMBOSIS AND FACTOR-V LEIDEN MUTATION
    ALHENCGELAS, M
    GANDRILLE, S
    AUBRY, ML
    EMMERICH, J
    FIESSINGER, JN
    AIACH, R
    [J]. LANCET, 1994, 344 (8921): : 555 - 556
  • [25] The factor V Leiden mutation in children with cancer and thrombosis
    Sifontes, MT
    Nuss, R
    Hunger, SP
    Wilimas, J
    Jacobson, LJ
    MancoJohnson, MJ
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 1997, 96 (03) : 484 - 489
  • [26] Combined severe factor XII deficiency and homozygous factor V Leiden mutation in a patient with venous thrombosis
    Miljic, P
    Colovic, M
    Boskovic, D
    Rakicevic, L
    Djordjevic, V
    [J]. THROMBOSIS RESEARCH, 2002, 106 (4-5) : 265 - 267
  • [27] Arterial thrombosis in mice with factor V Leiden mutation
    Sampram, Ellis S.
    Saad, Yasser
    Ouriel, Kenneth
    [J]. VASCULAR, 2008, 16 (01) : 31 - 34
  • [28] Factor V Leiden mutation does not account for central venous catheter-related thrombosis
    Riordan, M
    Weiden, PL
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 1998, 58 (02) : 150 - 152
  • [29] Selectin haplotypes and the risk of venous thrombosis: influence of linkage disequilibrium with the factor V Leiden mutation
    De Willige, S. Uitte
    De Visser, M. C. H.
    Vos, H. L. .
    Houwing-Duistermaat, J. J.
    Rosendaal, F. R.
    Bertina, R. M.
    [J]. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2008, 6 (03) : 478 - 485
  • [30] The factor V Leiden mutation increases the risk of venous thrombosis in patients with inflammatory bowel disease
    Liebman, HA
    Ashani, N
    Sutherland, D
    McGehee, W
    Kam, L
    [J]. GASTROENTEROLOGY, 1998, 115 (04) : 830 - 834
12345