The role of chance in cancer causation

被引：0

作者：

Angelini, Marco ^{[1
]}

Collatuzzo, Giulia ^{[1
]}

Teglia, Federica ^{[1
]}

Sassano, Michele ^{[1
]}

Siea, Andrei Cosmin ^{[1
]}

Boffetta, Paolo ^{[1
,2
]}

机构：

[1] Univ Bologna, Dept Med & Surg Sci, Via Massarenti 9, I-40138 Bologna, Italy

[2] SUNY Stony Brook, Stony Brook Canc Ctr, Stony Brook, NY 11794 USA

来源：

MEDICINA DEL LAVORO | 2022年 / 113卷 / 06期

关键词：

Cancer causation; susceptibility; carcinogenesis; cancer prevention; MULTIPLE ENDOCRINE NEOPLASIA; DNA-DAMAGE RESPONSE; OLDEST-OLD; RISK; MUTATIONS; LUNG; TUMORS; GENE;

D O I：

10.23749/mdl.v113i6.13867

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In the last years, the discussion about the role of chance in the causation of cancer has generated a large scientific and public debate. The concept that chance, or "bad luck", as responsible for a majority of the variation of cancer incidence, may be misleading, possibly causing an underestimation of the role played by known risk factors. In this commentary we discuss how host and external factors interact with chance in cancer causation in different ways, and provide examples of situations where chance appears to play only a minor role on cancer onset.

引用

页数：8

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