New chemical tools for disrupting the MDM2/p53 protein-protein interaction: Identification, synthesis and biological evaluation of a novel class of MDM2/p53 inhibitors

被引:0
|
作者
Pernazza, Daniele [1 ]
Li, Xiaolong [1 ]
Lawrence, Harshani R. [1 ]
Guida, Wayne C. [1 ]
DuBoulay, Courtney J. [2 ]
Watts, Shawn [3 ]
Sebti, Sayd M. [1 ]
Chen, Jiandong [1 ]
Lawrence, Nicholas J. [1 ]
机构
[1] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA
[2] Univ S Florida, Tampa, FL USA
[3] Schrodinger Inc, New York, NY USA
关键词
D O I
10.1158/1538-7445.AM2011-3242
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3242
引用
收藏
页数:2
相关论文
共 50 条
  • [21] A novel protein-protein interaction involving the MDM2 oncoprotein regulates p53 activity in response to hypoxia
    Mirnezami, AH
    Campbell, SJ
    Primrose, JN
    Johnson, PW
    Blaydes, JP
    BRITISH JOURNAL OF SURGERY, 2003, 90 (05) : 606 - 606
  • [22] Mathematical Simulation of p53–Mdm2 Protein Biological System Regulation
    O. F. Voropaeva
    Yu. I. Shokin
    L. M. Nepomnyashchikh
    S. R. Senchukova
    Bulletin of Experimental Biology and Medicine, 2014, 157 : 535 - 538
  • [23] Inorganic arsenic induces MDM2, p53, and their phosphorylation and affects the MDM2/p53 complex in vitro
    Jinyao Yin
    Qian Zhou
    Jingwen Tan
    Wangjun Che
    Yuefeng He
    Environmental Science and Pollution Research, 2022, 29 : 88078 - 88088
  • [24] The contribution of the acidic domain of MDM2 to p53 and MDM2 stability
    Manuela Argentini
    Nadia Barboule
    Bohdan Wasylyk
    Oncogene, 2001, 20 : 1267 - 1275
  • [25] The contribution of the acidic domain of MDM2 to p53 and MDM2 stability
    Argentini, M
    Barboule, N
    Wasylyk, B
    ONCOGENE, 2001, 20 (11) : 1267 - 1275
  • [26] MDM2 AND P53 - A QUESTION OF BALANCE
    MELTZER, PS
    JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (17) : 1265 - 1266
  • [27] p53 and Mdm2: An auld alliance
    Vigneron, Arnaud
    Vousden, Karen H.
    CELL CYCLE, 2010, 9 (05) : 865 - 866
  • [28] p53 ubiquitination: Mdm2 and beyond
    Brooks, CL
    Gu, W
    MOLECULAR CELL, 2006, 21 (03) : 307 - 315
  • [29] The p53 and Mdm2 families in cancer
    Michael, D
    Oren, M
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2002, 12 (01) : 53 - 59
  • [30] P53 degradation by Mdm2 - A novel mechanism for regulation of p53 stability
    Nampoothiri, VK
    CURRENT SCIENCE, 1998, 75 (09): : 875 - 877