A General Method for the Enantioselective Synthesis of α-Chiral Heterocycles

被引：63
|
作者：
Le, Phong Q. [1 ]
Nguyen, Thien S. [1 ]
May, Jeremy A. [1 ]
机构：
[1] Univ Houston, Dept Chem, Houston, TX 77204 USA
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 23期
关键词：
ASYMMETRIC CONJUGATE ALKENYLATION; ACYL IMINES; ARYLBORONIC ACIDS; ENONES; ALLYLBORATION; BIPHENOLS; KETONES; INDOLES; DIOLS; 1,4-ADDITION;
D O I：
10.1021/ol3030605
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The enantioselective formation of stereocenters proximal to unprotected heterocycles has been accomplished. Thus, vinyl boronic acids are added to heterocycle-appended enones via a modified-BINOL catalyst. Catalyst design was key to enable a general reaction. High yields and useful er's are observed for a host of common heteroaryls.
引用
收藏
页码：6104 / 6107
页数：4
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