How signaling promotes stem cell survival: Trophoblast stem cells and Shp2

被引：18

作者：

Ralston, A

Rossant, J

机构：

[1] Hosp Sick Children, Program Dev Biol, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON M5G 1X8, Canada

来源：

DEVELOPMENTAL CELL | 2006年 / 10卷 / 03期

关键词：

D O I：

10.1016/j.devcel.2006.02.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Trophoblast stem (TS) cells require FGF4 for self-renewal and to prevent differentiation. In this issue of Developmental Cell, Yang and colleagues show that the tyrosine phosphatase Shp2 prevents apoptosis in TS cells, by activation of Erk and subsequent phosphorylation and destabilization of the pro-apoptotic protein Bim. These studies provide a novel link between FGF/Erk signaling and cell survival that may be relevant to other stem and progenitor cell niches.

引用

页码：275 / 276

页数：2

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