Synthesis and Antibacterial Evaluation of 2-Ethyl-1-(4-substituted)phenyl-1H-imidazole Derivatives as Open-Chain Analogues of 7-Alkoxyl-4,5-dihydroimidazo[1,2-a]quinolines

被引：3
|
作者：
Sun, Xian-Yu [1 ]
Liu, Mei-Yu [1 ]
Zhong, Chun-Yan [1 ]
Zheng, Gui-Lin [1 ]
Lv, Ming-Yue [1 ]
Jing, Bo-Tao [1 ]
Pan, Chun-Yuan [1 ]
Wang, Xin [1 ]
机构：
[1] Bayi Agr Univ, Coll Anim Sci & Tech, Daqing 163319, Heilongjiang, Peoples R China
来源：
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2018年 / 29卷 / 04期
基金：
中国国家自然科学基金;
关键词：
2-ethyl-1-(4-substituted)phenyl-1H-imidazole; drug design; MIC; antibacterial activity; QUINOLINE DERIVATIVES; IN-SILICO; DESIGN;
D O I：
10.21577/0103-5053.20170190
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel series of 2-ethyl-1-(4-substituted)phenyl-1H-imidazole derivatives was designed, synthesized, and tested for its antibacterial activity against various bacterial strains. Most of the synthesized compounds showed potent inhibition of several Gram-positive and Gramnegative bacterial strains with minimum inhibitory concentration (MIC) values in the range of 4-256 nmol mL(-1) in vitro. The compound [2-ethyl-1-(4-pentoxy)phenyl-1H-imidazole] exhibited the most potent inhibitory activity. The MIC of this compound against S. aureus was found to be 8 nmol mL(-1), smaller than that of the reference agents, ciprofloxacin and amoxicillin. Furthermore, the compound exhibited modest activity against several bacterial strains in a dose range of 8-256 nmol mL(-1).
引用
收藏
页码：701 / 707
页数：7
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