Simple reduction of ethyl, isopropyl and benzyl aromatic esters to alcohols using sodium borohydride-methanol system

被引：30

作者：

da Costa, JCS ^{[1
]}

Pais, KC ^{[1
]}

Fernandes, EL ^{[1
]}

de Oliveira, PSM ^{[1
]}

Mendonça, JS ^{[1
]}

de Souza, MVN ^{[1
]}

Peralta, MA ^{[1
]}

Vasconcelos, TRA ^{[1
]}

机构：

[1] Fiocruz MS, Fdn Oswaldo Cruz, Inst Tecnol Farmacos Far Manguinhos, Rua Sizenando Nabuco,100, BR-21041250 Rio De Janeiro, Brazil

来源：

ARKIVOC | 2006年

关键词：

NaBH4; aromatic esters; reduction;

D O I：

10.3998/ark.5550190.0007.115

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several aromatic ethyl, isopropyl and benzyl esters were reduced to their corresponding alcohols in sodium borohydride-methanol system. The reductions were completed within 15-60 minutes in refluxing THF. The alcohol products were isolated after aqueous workup in good to excellent yields (63-100%). The general procedure presented is simple, safe, inexpensive and with good perspective in industrial scale.

引用

页码：128 / 133

页数：6

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