Simple reduction of ethyl, isopropyl and benzyl aromatic esters to alcohols using sodium borohydride-methanol system

被引：30
|
作者：
da Costa, JCS [1 ]
Pais, KC [1 ]
Fernandes, EL [1 ]
de Oliveira, PSM [1 ]
Mendonça, JS [1 ]
de Souza, MVN [1 ]
Peralta, MA [1 ]
Vasconcelos, TRA [1 ]
机构：
[1] Fiocruz MS, Fdn Oswaldo Cruz, Inst Tecnol Farmacos Far Manguinhos, Rua Sizenando Nabuco,100, BR-21041250 Rio De Janeiro, Brazil
来源：
ARKIVOC | 2006年
关键词：
NaBH4; aromatic esters; reduction;
D O I：
10.3998/ark.5550190.0007.115
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Several aromatic ethyl, isopropyl and benzyl esters were reduced to their corresponding alcohols in sodium borohydride-methanol system. The reductions were completed within 15-60 minutes in refluxing THF. The alcohol products were isolated after aqueous workup in good to excellent yields (63-100%). The general procedure presented is simple, safe, inexpensive and with good perspective in industrial scale.
引用
收藏
页码：128 / 133
页数：6
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