Novel small molecule therapeutics in rheumatoid arthritis

被引:32
|
作者
Kelly, Victoria [1 ]
Genovese, Mark [1 ]
机构
[1] Stanford Univ, Div Rheumatol & Immunol, Palo Alto, CA 94304 USA
关键词
DMARDs; treatment; rheumatoid arthritis; small molecules; kinase; JAK; SYK; BTK; PI3K; PDE4; X-LINKED AGAMMAGLOBULINEMIA; NECROSIS-FACTOR-ALPHA; TYROSINE KINASE SYK; B-CELL DEVELOPMENT; PHOSPHODIESTERASE INHIBITORS; IMMUNE-SYSTEM; MICE LACKING; DEFICIENCY; DISEASES; GENE;
D O I
10.1093/rheumatology/kes367
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A new wave of emerging therapies for the treatment of autoimmune and inflammatory diseases is under development. These therapies interrupt intracellular signalling through kinase inhibition. By interrupting one or more kinases it is possible to modulate the function of cellular structures such as surface receptors, signalling proteins and transcription of nuclear proteins and thus influence the behaviour of the cell types targeted. With these advances comes the significant potential to develop highly effective orally bioavailable therapeutics. The targets generating the greatest enthusiasm at this time for the treatment of autoimmune and inflammatory diseases include Janus-associated kinase, spleen tyrosine kinase, phosphodiesterase-4, Bruton's tyrosine kinase and phosphatidylinositol-3 kinase. Ultimately human trials will help us understand the potential risks and benefits of these novel approaches across a number of diseases.
引用
收藏
页码:1155 / 1162
页数:8
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