UV-Induced 1,3,4-Oxadiazole Formation from 5-Substituted Tetrazoles and Carboxylic Acids in Flow

被引：12

作者：

Green, Luke ^{[1
,2
]}

Livingstone, Keith ^{[1
]}

Bertrand, Sophie ^{[2
]}

Peace, Simon ^{[2
]}

Jamieson, Craig ^{[1
]}

机构：

[1] Univ Strathclyde, Dept Pure & Appl Chem, 295 Cathedral St, Glasgow G1 1XL, Lanark, Scotland

[2] GlaxoSmithKline, Med Res Ctr, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2020年 / 26卷 / 65期

基金：

英国工程与自然科学研究理事会;

关键词：

flow; heterocycles; Huisgen reaction; nitrile imines; photochemistry; THERMAL-DECOMPOSITION; NITRILE IMINES; DERIVATIVES; SELECTIVITY; LIGHT;

D O I：

10.1002/chem.202002896

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A range of 1,3,4-oxadiazoles have been synthesized using a UV-B activated flow approach starting from carboxylic acids and 5-substituted tetrazoles. The application of UV light represents an attractive alternative to the traditional thermolytic approach and has demonstrated comparable efficiency and versatility, with a diverse substrate scope, including the incorporation of highly substituted amino acids.

引用

页码：14866 / 14870

页数：5

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