Kinetics of immune response to foot-and-mouth disease virus (type Asia 1) in experimental cattle

被引：4
|
作者：
Mohan, M. S. [2 ]
Gajendragad, M. R. [1 ]
Kishore, Subodh [2 ]
Gopalakrishna, S. [2 ]
Singh, Nem [3 ]
机构：
[1] Project Directorate Anim Dis Monitoring & Surveil, Bangalore 560024, Karnataka, India
[2] Indian Vet Res Inst, Bangalore 560024, Karnataka, India
[3] Indian Vet Res Inst, Joint Directorate Res, Izatnagar 234143, Uttar Pradesh, India
来源：
VETERINARY RESEARCH COMMUNICATIONS | 2009年 / 33卷 / 02期
关键词：
Cattle; FMDV; Humoral immune response; Mucosal immune response; Neutralizing antibody titres; Secretory antibody response; Serum antibody response; ANTIBODY-RESPONSE; LIVE VIRUS; VACCINATION;
D O I：
10.1007/s11259-008-9076-4
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Humoral and mucosal (secretory antibody)immune response to FMDV type Asia 1 in cattle was analyzed after vaccination and infection using virus neutralizing test (VNT). Vaccination (1/16th the usual dose) failed to protect cattle from generalized clinical disease following experimental FMDV Asia 1 infection. Our results showed that infection induced higher and prolonged serum antibody titres indicating antigen mass is important for optimal immune response. Experimental FMDV infection induced significant secretory antibody (mucosal) response in cattle. Though, there was no difference in the serum antibody response between the cattle that developed generalized infection (unprotected) and those with only localized infection (protected), secretory antibody response differed, wherein the unprotected cattle had higher secretory response than protected cattle. Thus, FMDV Asia 1 infection stimulates a similar serum antibody response and a unique secretory antibody response among the infected cattle.
引用
收藏
页码：103 / 109
页数：7
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