Easy access to synthesize isoquinolines from aryl ketoximes and internal alkynes via Iridium (III)-catalyzed C-H/N-O bond activation

被引：13

作者：

Lin, Wei ^{[1
]}

Hu, Xiu-Xiu ^{[1
]}

Zhuang, Cang-Wei ^{[1
]}

Wang, Ya-Zhen ^{[1
]}

机构：

[1] Jiangsu Univ Technol, Sch Chem & Environm Engn, Changzhou 213001, Peoples R China

来源：

TETRAHEDRON | 2019年 / 75卷 / 22期

关键词：

Isoquinoline; Synthesis; Cyclization; Iridium(III)-catalysis; H FUNCTIONALIZATION; BETA-PHENYLETHYLAMINES; DIRECTING GROUPS; 4+2 ANNULATION; N-OXIDE; AMIDATION; OXIMES; ALKYNYLATION; HETEROCYCLES; CYCLIZATION;

D O I：

10.1016/j.tet.2019.04.039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient approach to synthesize isoquinoline derivatives through Iridium(III)-catalyzed cyclization of aryl ketoximes and internal alkynes without oxidant is reported. A broad range isoquinolines are obtained in good to excellent yields and various functional groups are well tolerated. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：3015 / 3023

页数：9

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