Catalyst-free diastereoselective synthesis of 2-methyl-4-amino-1,2,3,4-tetrahydro-quinoline derivatives in water

被引：7

作者：

Wu, Lin ^{[1
]}

Jiang, Ran ^{[2
]}

Yang, Jin-Ming ^{[1
]}

Wang, Shun-Yi ^{[2
]}

Ji, Shun-Jun ^{[2
]}

机构：

[1] Yancheng Teachers Univ, Coll Chem & Chem Engn, Key Lab Coastal Wetland Bioresources & Environm P, Yancheng 224002, Peoples R China

[2] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 22期

基金：

中国国家自然科学基金;

关键词：

Catalyst free; Tetrahydroquinoline; Water; Diastereoselective; tert-Enamides; DIELS-ALDER REACTION; ORGANIC-REACTIONS; AQUEOUS-MEDIA; NUCLEOPHILIC SUBSTITUTIONS; FACILE SYNTHESIS; ACID; QUINOLINE; EFFICIENT; ALCOHOLS; COPPER;

D O I：

10.1016/j.tetlet.2013.03.091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A diastereoselective synthesis of 2-methyl-4-amino-1,2,3,4-tetrahydro-quinoline derivatives was achieved through the reaction of aromatic amines and tert-enamides in water under reflux conditions. The desired products could be obtained in moderate to excellent yields utilizing water as solvent without any catalyst or additive. (C) 2013 Published by Elsevier Ltd.

引用

页码：2849 / 2852

页数：4

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