Primary CNS lymphoma: a clinician's guide

被引：0

作者：

Schaefer, Niklas ^{[1
]}

Glas, Martin ^{[1
,2
]}

Herrlinger, Ulrich ^{[1
]}

机构：

[1] Univ Hosp Bonn, Dept Neurol, Div Clin Neurooncol, Bonn, Germany

[2] Univ Bonn, Inst Reconstruct Neurobiol & Stem Cell Pathol Lif, Bonn, Germany

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2012年 / 12卷 / 10期

关键词：

autologous stem cell transplantation; HD-MTX; intraventricular therapy; lymphoma; neurotoxicity; PCNSL; polychemotherapy; NERVOUS-SYSTEM LYMPHOMA; HIGH-DOSE METHOTREXATE; WHOLE-BRAIN RADIOTHERAPY; NON-HODGKINS-LYMPHOMA; UNDER-THE-CURVE; POLYMERASE-CHAIN-REACTION; STEM-CELL RESCUE; QUALITY-OF-LIFE; TERM-FOLLOW-UP; ELDERLY-PATIENTS;

D O I：

10.1586/ERN.12.120

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Expert Rev. Neurother. 12(10), 1197-1206 (2012) Primary CNS lymphoma is a high malignant disease of the brain which can lead rapidly to death if diagnosis and/or the start of treatment is delayed. The age at time of diagnosis is a strong factor influencing prognosis so that in younger patients <65 years of age long-term survival may be achieved in a substantial percentage of patients, while in elderly patients long-term survival is seen much more rarely. First-line therapy consists of high-dose methotrexate-based (poly) chemotherapy. This review provides an overview of clinical presentation, steps to diagnosis, detailed information about current treatment concepts and specific information for particular clinical situations.

引用

页码：1197 / 1206

页数：10

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