The elusive engram: what can infantile amnesia tell us about memory?

被引:40
|
作者
Callaghan, Bridget L. [1 ]
Li, Stella [1 ]
Richardson, Rick [1 ]
机构
[1] Univ New S Wales, Sch Psychol, Sydney, NSW, Australia
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
infantile amnesia; memory; engram; forgetting; molecular mechanisms; LONG-TERM POTENTIATION; MEDIAL PREFRONTAL CORTEX; EPIGENETIC REGULATION; BASOLATERAL AMYGDALA; SYNAPTIC PLASTICITY; FEAR MEMORIES; LEARNED FEAR; STORAGE; CALCINEURIN; EXPRESSION;
D O I
10.1016/j.tins.2013.10.007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Revealing the engram is one of the greatest challenges in neuroscience. Many researchers focus on understanding the cellular and molecular mechanisms underlying the formation and maintenance of the engram, but an under-utilized approach has been to investigate analogous processes associated with forgetting. Infant rodents present an ideal model for this purpose because they display a rapid form of non-pathological forgetting known as infantile amnesia (IA). Despite the widespread importance of this interesting phenomenon, the study of the neural bases of IA has remained largely neglected. Here, we consider what IA can tell us about memory. We argue that to understand the mechanisms underlying the engram we must also gain an appreciation of the mechanisms that drive forgetting.
引用
收藏
页码:47 / 53
页数:7
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