Photoinduced Copper-Catalyzed Site-Selective C(sp2)-C(sp) Cross-Coupling via Aryl Sulfonium Salts

被引：45
|
作者：
Liang, Lei [1 ]
Niu, Hong-Ying [1 ]
Li, Ren-Long [1 ]
Wang, Yao-Fei [1 ]
Yan, Jin-Kai [1 ]
Li, Chang-Gong [1 ]
Guo, Hai-Ming [2 ]
机构：
[1] Henan Inst Sci & Technol, Sch Chem & Chem Engn, Xinxiang 453003, Henan, Peoples R China
[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 17期
基金：
中国国家自然科学基金;
关键词：
SONOGASHIRA REACTION; REDUCTION; LIGHT;
D O I：
10.1021/acs.orglett.0c02364
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The classical Sonogashira reaction of aryl electrophiles in the presence of Pd catalysts has been well established as a potent method for arylalkyne synthesis. However, the site-selective C(sp(2))-C(sp) cross-coupling strategy using a non-noble-metal catalyst is rare. An efficient alternative approach for the synthesis of arylalkynes via a Cu-catalyzed Sonogashira-type reaction promoted by visible light is described. This method enables site-selective alkynylation from aryl sulfonium salts derived from diverse arenes to a set of arylalkynes with high selectivity and high functional-group compatibility. Moreover, rapid alkynylation of drug molecules is demonstrated.
引用
收藏
页码：6842 / 6846
页数：5
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